Tuberc Respir Dis.  2007 Feb;62(2):113-118. 10.4046/trd.2007.62.2.113.

Efficacy of deferoxamine on paraquat poisoning

  • 1Department of Internal Medicine Inje University, Korea.
  • 2Department of Internal Medicine University of Ulsan, Korea.
  • 3Division of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea.


BACKGROUND: Paraquat is known to induce oxidant injury that results in multiorgan failure and lung fibrosis. Iron has been considered to play a key role in paraquat-induced oxidant lung injury. This study examined the effect of deferoxamine, an iron-chelating agent, in the treatment of paraquat poisoning.
From September, 2001 to April, 2005, 28 patients with paraquat poisoning who were admitted at a medical intensive care unit of a University-affiliated hospital, were enrolled in this study. Sixteen patients were treated according to the paraquat poisoning treatment guidelines and 12 received an intravenous infusion of deferoxamine in addition to the treatment guidelines.
There were no differences between the two groups in terms of age, gender, severity of paraquat poisoning, and the time elapsed from ingestion to presentation at hospital. There was no difference in overall mortality between the two groups but the incidence of respiratory failure in the deferoxamine group was higher than in the conventional group(4/7 versus 0/9, p=0.019).
Deferoxamine seems to have no clinical benefit compared with the conventional treatment.


Paraquat; Deferoxamine; Mortality

MeSH Terms

Infusions, Intravenous
Intensive Care Units
Lung Injury
Respiratory Insufficiency


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