Tuberc Respir Dis.  2007 Feb;62(2):113-118. 10.4046/trd.2007.62.2.113.

Efficacy of deferoxamine on paraquat poisoning

Affiliations
  • 1Department of Internal Medicine Inje University, Korea.
  • 2Department of Internal Medicine University of Ulsan, Korea.
  • 3Division of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea. yskoh@amc.seoul.kr

Abstract

BACKGROUND: Paraquat is known to induce oxidant injury that results in multiorgan failure and lung fibrosis. Iron has been considered to play a key role in paraquat-induced oxidant lung injury. This study examined the effect of deferoxamine, an iron-chelating agent, in the treatment of paraquat poisoning.
METHODS
From September, 2001 to April, 2005, 28 patients with paraquat poisoning who were admitted at a medical intensive care unit of a University-affiliated hospital, were enrolled in this study. Sixteen patients were treated according to the paraquat poisoning treatment guidelines and 12 received an intravenous infusion of deferoxamine in addition to the treatment guidelines.
RESULTS
There were no differences between the two groups in terms of age, gender, severity of paraquat poisoning, and the time elapsed from ingestion to presentation at hospital. There was no difference in overall mortality between the two groups but the incidence of respiratory failure in the deferoxamine group was higher than in the conventional group(4/7 versus 0/9, p=0.019).
CONCLUSIONS
Deferoxamine seems to have no clinical benefit compared with the conventional treatment.

Keyword

Paraquat; Deferoxamine; Mortality

MeSH Terms

Deferoxamine*
Eating
Fibrosis
Humans
Incidence
Infusions, Intravenous
Intensive Care Units
Iron
Lung
Lung Injury
Mortality
Paraquat*
Poisoning*
Respiratory Insufficiency
Deferoxamine
Iron
Paraquat

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