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Characteristics of Acute Herbicide Poisoning: Focused on Chlorophenoxy Herbicide

Song H, Choi S, Jung YS, Park E, Kim H

PURPOSE: Herbicide-related mortality has decreased since the complete ban of paraquat product sales in 2012, but there still have been other herbicides intoxications with relatively severe complications. Glyphosate and glufosinate...
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A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals

Kim HR, Shin DY, Chung KH

Several studies showed that the inflammatory and fibrotic responses induced by polyhexamethylene guanidine phosphate (PHMG-p) were similar to those observed for idiopathic pulmonary fibrosis in South Korea in 2011. “Omic”...
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The Burden of Acute Pesticide Poisoning and Pesticide Regulation in Korea

Ko S, Cha ES, Choi Y, Kim J, Kim JH, Lee WJ

BACKGROUND: This study aimed to estimate the burden of acute pesticide poisoning and to determine its trend with recently implemented pesticide regulations. METHODS: Disability-adjusted life-years (DALYs) were calculated as the sum...
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Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung injury in rats with paraquat intoxication

Gao J, Feng S, Li Y

BACKGROUND/AIMS: This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats. METHODS: PQ (25 mg/kg) was administered intraperitoneally to induce...
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Effects of Paraquat Ban on Herbicide Poisoning-Related Mortality

Ko DR, Chung SP, You JS, Cho S, Park Y, Chun B, Moon J, Kim H, Kim YH, Kim HJ, Lee KW, Choi S, Park J, Park JS, Kim SW, Seo JY, Park HY, Kim SJ, Kang H, Hong DY, Hong JH

PURPOSE: In Korea, registration of paraquat-containing herbicides was canceled in November 2011, and sales thereof were completely banned in November 2012. We evaluated the effect of the paraquat ban on...
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Epidemiologic Characteristics of Intentional Poisoning: Emergency Department Based Injury in-depth Surveillance During 2011–2015

Lee HS, Han J, Kim JH, Kim S, Kim SH, Lee JS, Cho GC, Han C, Park JM, Chung SP, Kim MJ

PURPOSE: The purpose of this study was to investigate the epidemiologic characteristics of patients who visited emergency departments (EDs) after intentional poisoning in Korea. METHODS: This study retrospectively analyzed the data...
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Analysis of Poisoning Patients Using 2016 ED Based Injury in-depth Surveillance Data

Chung SP, Lee MJ, Kang H, Oh BJ, Kim H, Kim YW, Chun BJ, Kim KH

PURPOSE: Some advanced countries have reported annual statistics for poisoning based on data from poison control centers. This study was conducted to propose a baseline format and statistics of poisoning...
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Urine Methyl Hippuric Acid Levels in Acute Pesticide Poisoning: Estimation of Ingested Xylene Volume and Association with Clinical Outcome Parameters

Choi CY, Cho N, Park SY, Park S, Gil HW, Hong SY

To determine the relationship between the oral ingestion volume of xylene and methyl hippuric acid (MHA) in urine, we measured MHA in 11 patients whose ingested xylene volume was identified....
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Predicting the probability of survival in acute paraquat poisoning

Sun IO, Shin SH, Yoon HJ, Lee KY

BACKGROUND: Paraquat (PQ) concentration-time data have been used to predict prognosis for 3 decades. The aim of this study was to find a more accurate method to predict the probability...
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High yields and soluble expression of superoxide dismutases in Escherichia coli due to the HIV-1 Tat peptide via increases in mRNA transcription

Sun Y, Ye Q, Wu M, Wu Y, Zhang C, Yan W

This study aimed to validate the high yield and soluble expression of proteins carrying the transactivator of transcription (Tat) peptide tag, and further explored the potential mechanism by which the...
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Toxicokinetics of paraquat in Korean patients with acute poisoning

Kim HJ, Kim HK, Lee H, Bae JS, Kown JT, Gil HW, Hong SY

To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit...
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Chest Radiographic Findings in Acute Paraquat Poisoning

Na GG, Lee MS, Noh KH, Kim HJ, Sun IO

PURPOSE: To describe the chest radiographic findings of acute paraquat poisoning. MATERIALS AND METHODS: 691 patients visited the emergency department of our hospital between January 2006 and October 2012 for paraquat...
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Paraquat Induces Apoptosis through a Mitochondria-Dependent Pathway in RAW264.7 Cells

Jang YJ, Won JH, Back MJ, Fu Z, Jang JM, Ha HC, Hong S, Chang M, Kim DK

Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has...
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Homicidal Paraquat Poisoning in Exhumed Case

Park S, Jeong S, Lee HY

Paraquat is a nonselective herbicide, but its lethal and toxic effects are well known. Although its chemical additives have an unpleasant taste, this can be shrouded in spicy foods or...
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Common Pesticides Used in Suicide Attempts Following the 2012 Paraquat Ban in Korea

Lee JW, Hwang IW, Kim JW, Moon HJ, Kim KH, Park S, Gil HW, Hong SY

To determine the change in pesticides used during suicide attempts after the 2012 paraquat (PQ) ban, we evaluated the annual number of suicide attempts by pesticide ingestion between 2011 and...
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Two Successfully Treated Cases of Pulmonary Fibrosis Due to Paraquat Poisoning

Lee WK, Seong CS, Kim BS, Choi HM, Lee HS, Yoon HJ, Kim JG, Lee MS, Lee KY, Sun IO

Paraquat poisoning can cause severe multiple organ failure involving the kidneys, liver, lungs, adrenals, and central nervous system. The toxic effect of paraquat on the lung manifests as pulmonary edema,...
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Paraquat Induces Apoptosis through Cytochrome C Release and ERK Activation

Seo HJ, Choi SJ, Lee JH

Paraquat has been suggested to induce apoptosis by generation of reactive oxygen species (ROS). However, little is known about the mechanism of paraquat-induced apoptosis. Here, we demonstrate that extracellular signal-regulated...
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Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication

Gil HW, Hong JR, Jang SH, Hong SY

Paraquat (PQ) has known negative human health effects, but continues to be commonly used worldwide as a herbicide. Our clinical data shows that the main prognostic factor is the time...
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Erythema Multiforme-like Eruptions Caused by Accidental Exposure to Glufosinate Ammonium

Yoon SD, Lee KS, Cho JW

  • KMID: 1734193
  • Korean J Dermatol.
  • 2014 Nov;52(11):809-812.
Glufosinate ammonium herbicide is a nonselective herbicide used worldwide because it is less toxic than paraquat. Acute glufosinate ammonium intoxications manifest as injuries of the intestinal mucosa, abdominal pain, vomiting,...
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The dose of cyclophosphamide for treating paraquat-induced rat lung injury

Choi JS, Jou SS, Oh MH, Kim YH, Park MJ, Gil HW, Song HY, Hong SY

BACKGROUND/AIMS: Cyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury. METHODS: Adult male Sprague-Dawley rats...
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