- The optimal model of reperfusion injury in vitro using H9c2 transformed cardiac myoblasts
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Son E, Lee D, Woo CW, Kim YH
- KMID: 2471039
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):173-183.
- doi: 10.4196/kjpp.2020.24.2.173
An in vitro model for ischemia/reperfusion injury has not been well-established. We hypothesized that this failure may be caused by serum deprivation, the use of glutamine-containing media, and absence of... -
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- Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells
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Hwang S, Kim JK
- KMID: 2468142
- Chonnam Med J.
- 2020 Jan;56(1):20-26.
- doi: 10.4068/cmj.2020.56.1.20
We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours... -
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- Hypoxia Enhances Osteogenic Differentiation in Retinoic Acid-Treated Murine-Induced Pluripotent Stem Cells
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Manokawinchoke J, Osathanon , Egusa H, Pavasant P
- KMID: 2360803
- Tissue Eng Regen Med.
- 2016 Oct;13(5):547-553.
- doi: 10.1007/s13770-016-9127-9
Hypoxic condition influences biological responses in various cell types. However, a hypoxic regulating osteogenic differentiation remains controversy. Here, an influence of short-term culture in hypoxic condition on osteogenic marker gene... -
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- Cutaneous Mucormycosis in a Patient with Diabetes Mellitus
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Park JH, Park SH, Kang EG, Kyung GC, An HD, An SY
- KMID: 2152751
- Ewha Med J.
- 2016 Jan;39(1):10-13.
- doi: 10.12771/emj.2016.39.1.10
Mucormycosis is a rare disease caused by fungi. Most commonly involved sites of mucormycosis infection are sinuses, lungs, skin and soft tissues. Systemic risk factors for mucormycosis are diabetes mellitus,... -
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- Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1alpha in a Rat Model of Bronchopulmonary Dysplasia
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Choi CW, Lee J, Lee HJ, Park HS, Chun YS, Kim BI
- KMID: 2344155
- J Korean Med Sci.
- 2015 Sep;30(9):1295-1301.
- doi: 10.3346/jkms.2015.30.9.1295
Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants... -
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- Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
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Kim YM, Song I, Seo YH, Yoon G
- KMID: 2169308
- Endocrinol Metab.
- 2013 Dec;28(4):297-308.
- doi: 10.3803/EnM.2013.28.4.297
BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an... -
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- The Experiences of the Emergency Antidote Stock and Delivery Service by the Korean Poison Information Center
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Park SY, Oh BJ, Sohn CH, Jeong RB, Lim KS, Kim W, Ryoo SM, The research society for emergency antidotes stock and delivery system in Korea
- KMID: 1482712
- J Korean Soc Clin Toxicol.
- 2013 Jun;11(1):9-18.
PURPOSE: Antidotes for toxicological emergencies can be life-saving. However, there is no nationwide stocking and delivery system for emergency antidotes in Korea. We report on a two-year experience of a... -
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- A Case of Acute Aluminum Encephalopathy with Intraperitoneal Bladder Rupture Following Aluminum Bladder Irrigation in a Patient with Normal Renal Function
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An YH, Kim SG, Park JY, Jang GS, Kim SY, Hong EY, An JS
- KMID: 2263486
- Korean J Med.
- 2012 Aug;83(2):258-262.
Acute aluminum intoxication is uncommon in clinical practice but can be fatal. Most cases have been reported in patients with decreased renal function, especially dialysis patients. We describe a case... -
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- The Role of Oxygen-Derived Free Radicals in Vascular Relaxations to Pinacidil in Renal Hypertensive Rats
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Choi S, Yoo IJ, Whi HW, Jun JY, Kim HI, Shin HR, Oh HJ, Chung JH, Yeum CH
- KMID: 2080107
- Korean J Nephrol.
- 2010 Nov;29(6):695-701.
PURPOSE: Evidence has emerged that oxygen-derived free radicals may induce vascular relaxations via ATP-sensitive K+ (K(ATP)) channels and the level of free radicals is increased in animal models of hypertension.... -
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- Effect of ketorolac and diclofenac on the impairment of endothelium-dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta
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Lee SY, Suh JK, Choi JH, Jeon WJ, Cheong MA
- KMID: 2239777
- Korean J Anesthesiol.
- 2010 Sep;59(3):196-202.
- doi: 10.4097/kjae.2010.59.3.196
BACKGROUND: Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in endothelium. We studied the influences of ketorolac and diclofenac on ROS effects using the endothelium of rabbit abdominal... -
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- Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta
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Lee JM, Suh JK, Jeong JS, Cho SY, Kim DW
- KMID: 1766371
- Korean J Anesthesiol.
- 2010 Aug;59(2):104-110.
- doi: 10.4097/kjae.2010.59.2.104
BACKGROUND: Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in the endothelium. We tested the antioxidant effect of lidocaine and procaine on ROS-induced endothelial damage in the rabbit... -
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- Effect of Iron-Chelator Deferiprone on the In Vitro Growth of Staphylococci
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Kim CM, Shin SH
- KMID: 1779132
- J Korean Med Sci.
- 2009 Apr;24(2):289-295.
- doi: 10.3346/jkms.2009.24.2.289
The standard iron-chelator deferoxamine is known to prevent the growth of coagulase-negative staphylococci (CoNS) which are major pathogens in iron-overloaded patients. However, we found that deferoxamine rather promotes the growth... -
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- Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
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Park EH, Lee HJ, Lee SY, Kim SY, Yi HK, Lee DY, Hwang PH
- KMID: 2281678
- Korean J Pediatr.
- 2009 Feb;52(2):213-219.
- doi: 10.3345/kjp.2009.52.2.213
PURPOSE: Iron is a critical nutritional element that is essential for a variety of important biological processes, including cell growth and differentiation, electron transfer reactions, and oxygen transport, activation, and... -
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- The effect of erythropoietin in neonatal rat model of hypoxic-ischemic brain injury
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Kim HM, Choe BH, Kwon SH, Sohn YK
- KMID: 2037345
- Korean J Pediatr.
- 2009 Jan;52(1):105-110.
- doi: 10.3345/kjp.2009.52.1.105
PURPOSE: Perinatal asphyxia is an important cause of neonatal mortality and subsequent lifelong neurodevelopmental handicaps. Although many treatment strategies have been tested, there is currently no clinically effective treatment to... -
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- Acute Tubulointerstitial Nephritis Induced by Deferasirox following Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia
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Min JW, Hwang SJ, Lim YJ, Lee YH
- KMID: 1485085
- Korean J Hematol.
- 2008 Dec;43(4):258-262.
- doi: 10.5045/kjh.2008.43.4.258
Deferasirox is a once-daily, oral iron-chelating agent that is now widely available for the treatment of transfusional hemosiderosis. Deferasirox represents a significant advance in the treatment of iron overload, as... -
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- Comparison of Immune Responses Induced by Deferoxamine and Deferasirox
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Jung YS, Bae EY, Chung NG, Cho B, Kim HK, Min CK, Han CW, Kim HS, Jeong DC
- KMID: 2252181
- Korean J Hematol.
- 2008 Sep;43(3):150-158.
- doi: 10.5045/kjh.2008.43.3.150
BACKGROUND: The iron chelating agents (ICA) have various biological effects besides iron chelation. We investigated the immunomodulatory effects of Deferasirox (DFS) compared to Deferoxamine (DFO). METHODS: Spleen cells (SP) were obtained... -
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- Economic Evaluation of Iron Chelation Agents: Oral Deferasirox versus Infusional Deferoxamine
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Kim JH, Kim YH
- KMID: 2252201
- Korean J Hematol.
- 2008 Jun;43(2):89-97.
- doi: 10.5045/kjh.2008.43.2.89
BACKGROUND: Patients with transfusional iron overload have relied on treatment with deferoxamine, a standard chelating agent. Deferoxamine is administered by intravenous or subcutaneous infusion over an 8~12 hour period 5~7... -
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- Effects of Ascorbic and Dehydroascorbic Acids on Apoptotic Cell Death in Hippocampal Slice Culture
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Kim EJ, Won R, Lee KH, Kim UJ, Shim I, Lee HJ, Lee BH
- KMID: 2165279
- Exp Neurobiol.
- 2008 Jun;17(1):25-31.
- doi: 10.5607/en.2008.17.1.25
Ascorbic acid (AA) and dehydroascorbic acid (DHA) are known to have protective effects in experimental central nerve system disorder models such as stroke, ischemia, and epileptic seizures. The present study... -
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- Effects of Hypoxia on Vascular Endothelial Growth Factor and Fibroblast Growth Factor Expression in Eutopic Endometrium with Endometriosis
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Jeong KA, Chun SH, Yoon JM
- KMID: 1973944
- Ewha Med J.
- 2008 Jun;31(1):15-20.
- doi: 10.12771/emj.2008.31.1.15
OBJECTIVES: This study was performed to investigate the functional roles of hypoxia and HIF-1 alpha, leading to expression of VEGF and FGF in the pathogenesis of endometriosis. METHODS: From September 2005... -
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- Complete Hematopoietic Recovery after Continuous Iron Chelation Therapy in a Patient with Severe Aplastic Anemia with Secondary Hemochromatosis
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Park SJ, Han CW
- KMID: 1713468
- J Korean Med Sci.
- 2008 Apr;23(2):320-323.
- doi: 10.3346/jkms.2008.23.2.320
A 16-yr-old male patient with hemochromatosis due to multiple packed red blood cell transfusions was referred to our emergency center for the treatment of severe aplastic anemia and dyspnea. He... -
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