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The optimal model of reperfusion injury in vitro using H9c2 transformed cardiac myoblasts

Son E, Lee D, Woo CW, Kim YH

An in vitro model for ischemia/reperfusion injury has not been well-established. We hypothesized that this failure may be caused by serum deprivation, the use of glutamine-containing media, and absence of...
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Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells

Hwang S, Kim JK

We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours...
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Hypoxia Enhances Osteogenic Differentiation in Retinoic Acid-Treated Murine-Induced Pluripotent Stem Cells

Manokawinchoke J, Osathanon , Egusa H, Pavasant P

Hypoxic condition influences biological responses in various cell types. However, a hypoxic regulating osteogenic differentiation remains controversy. Here, an influence of short-term culture in hypoxic condition on osteogenic marker gene...
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Cutaneous Mucormycosis in a Patient with Diabetes Mellitus

Park JH, Park SH, Kang EG, Kyung GC, An HD, An SY

Mucormycosis is a rare disease caused by fungi. Most commonly involved sites of mucormycosis infection are sinuses, lungs, skin and soft tissues. Systemic risk factors for mucormycosis are diabetes mellitus,...
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Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1alpha in a Rat Model of Bronchopulmonary Dysplasia

Choi CW, Lee J, Lee HJ, Park HS, Chun YS, Kim BI

Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants...
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Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells

Kim YM, Song I, Seo YH, Yoon G

BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an...
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The Experiences of the Emergency Antidote Stock and Delivery Service by the Korean Poison Information Center

Park SY, Oh BJ, Sohn CH, Jeong RB, Lim KS, Kim W, Ryoo SM, The research society for emergency antidotes stock and delivery system in Korea

  • KMID: 1482712
  • J Korean Soc Clin Toxicol.
  • 2013 Jun;11(1):9-18.
PURPOSE: Antidotes for toxicological emergencies can be life-saving. However, there is no nationwide stocking and delivery system for emergency antidotes in Korea. We report on a two-year experience of a...
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A Case of Acute Aluminum Encephalopathy with Intraperitoneal Bladder Rupture Following Aluminum Bladder Irrigation in a Patient with Normal Renal Function

An YH, Kim SG, Park JY, Jang GS, Kim SY, Hong EY, An JS

  • KMID: 2263486
  • Korean J Med.
  • 2012 Aug;83(2):258-262.
Acute aluminum intoxication is uncommon in clinical practice but can be fatal. Most cases have been reported in patients with decreased renal function, especially dialysis patients. We describe a case...
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The Role of Oxygen-Derived Free Radicals in Vascular Relaxations to Pinacidil in Renal Hypertensive Rats

Choi S, Yoo IJ, Whi HW, Jun JY, Kim HI, Shin HR, Oh HJ, Chung JH, Yeum CH

  • KMID: 2080107
  • Korean J Nephrol.
  • 2010 Nov;29(6):695-701.
PURPOSE: Evidence has emerged that oxygen-derived free radicals may induce vascular relaxations via ATP-sensitive K+ (K(ATP)) channels and the level of free radicals is increased in animal models of hypertension....
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Effect of ketorolac and diclofenac on the impairment of endothelium-dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta

Lee SY, Suh JK, Choi JH, Jeon WJ, Cheong MA

BACKGROUND: Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in endothelium. We studied the influences of ketorolac and diclofenac on ROS effects using the endothelium of rabbit abdominal...
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Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta

Lee JM, Suh JK, Jeong JS, Cho SY, Kim DW

BACKGROUND: Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in the endothelium. We tested the antioxidant effect of lidocaine and procaine on ROS-induced endothelial damage in the rabbit...
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Effect of Iron-Chelator Deferiprone on the In Vitro Growth of Staphylococci

Kim CM, Shin SH

The standard iron-chelator deferoxamine is known to prevent the growth of coagulase-negative staphylococci (CoNS) which are major pathogens in iron-overloaded patients. However, we found that deferoxamine rather promotes the growth...
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Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells

Park EH, Lee HJ, Lee SY, Kim SY, Yi HK, Lee DY, Hwang PH

PURPOSE: Iron is a critical nutritional element that is essential for a variety of important biological processes, including cell growth and differentiation, electron transfer reactions, and oxygen transport, activation, and...
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The effect of erythropoietin in neonatal rat model of hypoxic-ischemic brain injury

Kim HM, Choe BH, Kwon SH, Sohn YK

PURPOSE: Perinatal asphyxia is an important cause of neonatal mortality and subsequent lifelong neurodevelopmental handicaps. Although many treatment strategies have been tested, there is currently no clinically effective treatment to...
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Acute Tubulointerstitial Nephritis Induced by Deferasirox following Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia

Min JW, Hwang SJ, Lim YJ, Lee YH

Deferasirox is a once-daily, oral iron-chelating agent that is now widely available for the treatment of transfusional hemosiderosis. Deferasirox represents a significant advance in the treatment of iron overload, as...
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Comparison of Immune Responses Induced by Deferoxamine and Deferasirox

Jung YS, Bae EY, Chung NG, Cho B, Kim HK, Min CK, Han CW, Kim HS, Jeong DC

BACKGROUND: The iron chelating agents (ICA) have various biological effects besides iron chelation. We investigated the immunomodulatory effects of Deferasirox (DFS) compared to Deferoxamine (DFO). METHODS: Spleen cells (SP) were obtained...
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Economic Evaluation of Iron Chelation Agents: Oral Deferasirox versus Infusional Deferoxamine

Kim JH, Kim YH

BACKGROUND: Patients with transfusional iron overload have relied on treatment with deferoxamine, a standard chelating agent. Deferoxamine is administered by intravenous or subcutaneous infusion over an 8~12 hour period 5~7...
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Effects of Ascorbic and Dehydroascorbic Acids on Apoptotic Cell Death in Hippocampal Slice Culture

Kim EJ, Won R, Lee KH, Kim UJ, Shim I, Lee HJ, Lee BH

Ascorbic acid (AA) and dehydroascorbic acid (DHA) are known to have protective effects in experimental central nerve system disorder models such as stroke, ischemia, and epileptic seizures. The present study...
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Effects of Hypoxia on Vascular Endothelial Growth Factor and Fibroblast Growth Factor Expression in Eutopic Endometrium with Endometriosis

Jeong KA, Chun SH, Yoon JM

OBJECTIVES: This study was performed to investigate the functional roles of hypoxia and HIF-1 alpha, leading to expression of VEGF and FGF in the pathogenesis of endometriosis. METHODS: From September 2005...
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Complete Hematopoietic Recovery after Continuous Iron Chelation Therapy in a Patient with Severe Aplastic Anemia with Secondary Hemochromatosis

Park SJ, Han CW

A 16-yr-old male patient with hemochromatosis due to multiple packed red blood cell transfusions was referred to our emergency center for the treatment of severe aplastic anemia and dyspnea. He...
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