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Isolation of Secretome with Enhanced Antifibrotic Properties from miR-214-Transfected Adipose-Derived Stem Cells

Park JH, Kim OH, Kim KH, Hong HE, Seo H, Choi HJ, Ahn J, Lee TY, Kim SJ

BACKGROUND: Secretome refers to the total set of molecules secreted or surface-shed by stem cells. The limitations of stem cell research have led numerous investigators to turn their attention to...
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The Cause and Treatment of Acute Kidney Injury

Oh SW

Acute kidney injury (AKI), characterized by an acute decline in renal function, commonly develops in hospitalized patients and is associated with increased morbidity and mortality. Recent studies have identified new...
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Anesthetic considerations during surgical intervention in Woake's syndrome: a case report

Choi SR, Kim JH, Chae KL, Lee SC, Park SY

BACKGROUND: Woake's syndrome (WS) is a recurrent nasal polyposis, accompanied by broadening of the nose, frontal sinus aplasia, dyscrinia, and bronchiectasis. There has been no previous report on anesthetic management...
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Symptomatic Hypocalcemia Associated with Dioscorea tokoro Toxicity

Yoon JC, Lee JB, Jeong TO, Jo SO, Jin YH

Dioscorea tokoro has long been used in Korean traditional medicine as a pain killer and anti-inflammatory agent. A 53-year-old male who consumed water that had been boiled with raw tubers...
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Adipose tissue-derived mesenchymal stromal cells for treating chronic kidney disease: A pilot study assessing safety and clinical feasibility

Villanueva S, González , Lorca E, Tapia A, Valentina López G, Strodthoff R, Fajre F, Carreño J, Valjalo R, Vergara C, Lecanda M, Bartolucci J, Figueroa F, Khoury M

BACKGROUND: Chronic kidney disease (CKD) is a growing public health concern, and available treatments are insufficient in limiting disease progression. New strategies, including regenerative cell-based therapies, have emerged as therapeutic...
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A Comparative Study on the Contamination Level of Intravenous Infusion Ports: A Comparison of 3-way Stopcock (Open-system) and Needleless Connector (Closed-system)

Jang BJ, Kim KS

BACKGROUND: This study was conducted to evaluate the level of intravenous injection port contamination in 3-way stopcock (open-system) or needleless connector (closed-system) intravenous infusion devices before and after disinfecting for...
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Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center

Jeong IJ, Hwang S, Jung DH, Song GW, Park GC, Ahn CS, Moon DB, Kim KH, Ha TY, Ha HS, Hong JJ, Kim IO, Lee SG

BACKGROUNDS/AIMS: This study intended to evaluate patient safety and efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin (HBIG) in recipients of hepatitis B virus-associated adult...
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Modulation of Renal Parenchyma in Response to Allogeneic Adipose-Derived Mesenchymal Stem Cells Transplantation in Acute Kidney Injury

Begum S, Ahmed N, Mubarak M, Mateen SM, Khalid N, Rizvi SA

BACKGROUND AND OBJECTIVES: In regenerative medicine, mesenchymal stem cells derived from adipose tissues (Ad-MSCs) are a very attractive target to treat many diseases. In relation to nephrology, the aim of...
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Pharmacological Treatment for Peptic Ulcer Bleeding

Ma DW, Kim BW

Peptic ulcer bleeding (PUB) is the most common cause of non-variceal upper gastrointestinal bleeding, and its frequency has been declining over the past decades. However, mortality from PUB persists, and...
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Treatment results of the second-line chemotherapy regimen for patients with low-risk gestational trophoblastic neoplasia treated with 5-day methotrexate and 5-day etoposide

Kanno T, Matsui H, Akizawa Y, Usui H, Shozu M

OBJECTIVE: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%–30% of patients treated with chemotherapy need to change...
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Postpartum Superior Sagittal Sinus Thrombosis: A Case Report

Han KH, Won YD, Na MK, Han MH, Ryu JI, Kim JM, Kim CH, Cheong JH

Cerebral venous sinus thrombosis (CVST) is a rare disease. Early diagnosis and treatment are important, as CVST is potentially fatal. Pregnancy and puerperium are known risk factors for CVST. Here,...
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Usefulness of serum lactate as a predictor of successful discontinuation of continuous atropine infusion in patients with severe acute organophosphate poisoning

Kwon HC, Cha YS, An GJ, Lee Y, Kim H

OBJECTIVE: In severe organophosphate (OP) poisoning, administration of atropine via continuous intravenous infusion is typically considered. To date, there have been no studies on predicting successful atropine discontinuation through plasma...
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The Effect of Intravenous Lipid Emulsion in a Rat Model of Verapamil Toxicity

Ha DM, Kim DH, Kim T, Lee SH, Jeong JH, Lee SB, Lim D, Kang C

PURPOSE: Intravenous lipid emulsion (ILE) has been shown to have significant therapeutic effects on calcium channel blocker overdose in animal studies and clinical cases. In this preliminary experiment, we investigated...
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Factors Related to Extravasation of Non-chemotherapy Vesicant Drugs in Peripheral Vein Catheters

Lee JM, Lee J, Jang YS, Kim YH

PURPOSE: This study aimed to investigate the incidence of intravenous extravasation and the risk factors associated with the use of peripheral intravenous catheters in adults. METHOD: This prospective observational study included...
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The Efficacy and Safety of Continuous Intravenous Infusion of Low-dose Epinephrine in Patients with Severe Acute Urticaria Who Do Not Achieve Sufficient Responses to Conventional Treatments: An 8-year Retrospective Study

Jeong WS, Hwangbo H, Lee SK

  • KMID: 2436684
  • Korean J Dermatol.
  • 2018 May;56(4):242-250.
BACKGROUND: Acute urticaria sometimes accompanies severe systemic reactions that can be potentially life-threatening. Some patients do not achieve sufficient responses to conventional treatments. There has been no previous study on...
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TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-Label, Non-randomized Phase 1 Study

Bang YJ, Takano T, Lin CC, Fasanmade , Yang H, Danaee H, Asato T, Kalebic T, Wang H, Doi T

PURPOSE: This phase 1 dose-escalation portion of the study evaluated the safety, pharmacokinetics (PK), and antitumor activity of TAK-264 in Asian patients with advanced gastrointestinal (GI) carcinoma or metastatic or...
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Sudden Deaths of Neonates Receiving Intravenous Infusion of Lipid Emulsion Contaminated with Citrobacter freundii

Bae JY, Kang CK, Choi SJ, Lee E, Choe PG, Park WB, Kim NJ, Kim EC, Oh MD

At an intensive care unit, four neonates died consecutively within 80 minutes. Citrobacter freundii was isolated from blood samples of the 4 patients. It was also cultured from the leftover...
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Life-Threatening Thrombocytopenia Following Intravenous Contrast Media Infusion

Park M, Kim M, Park J, Cho J

Radiocontrast media-induced acute severe thrombocytopenia is a very rare complication and potentially life-threatening. Here, we report the case of a 63-year-old male patient with severe acute thrombocytopenia following first exposure...
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Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial

Zhang J, Lv S, Liu X, Song B, Shi L

BACKGROUND/AIMS: Stem cell therapy has been applied to treat a variety of autoimmune diseases, including Crohn's disease (CD), but few studies have examined the use of umbilical cord mesenchymal stem...
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Hemodynamic Effects on Systemic Blood Flow and Ductal Shunting Flow after Loading Dose of Intravenous Caffeine in Preterm Infants according to the Patency of Ductus Arteriosus

Hwang J, Kim YS, Shin JH, Choi BM

BACKGROUND: In preterm infants, caffeine citrate is used to stimulate breathing before they are weaned from mechanical ventilation and to reduce the frequency of apnea. In recent studies, effects of...
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