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Clinical experience of hemoperfusion treatment in children with paraquat poisoning

Jeon HY, Roh DE

Paraquat is a fatal, rapid-acting, nonselective herbicide. Despite the restriction of production and sales of the herbicide in Korea since 2012, already purchased paraquat can incur poisoning. This article describes...
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Effect of Occupational Exposure to Herbicides on Oxidative Stress in Sprayers

Intayoung U, Wunnapuk K, Kohsuwan K, Sapbamrer R, Khacha-ananda S

Background: Herbicides such as glyphosate, paraquat, and 2,4-dichlorophenoxyacetic acid have been reported to cause adverse side effects through production of reactive oxygen species. However, there were no data representing the...
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Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung injury in rats with paraquat intoxication

Gao J, Feng S, Li Y

BACKGROUND/AIMS: This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats. METHODS: PQ (25 mg/kg) was administered intraperitoneally to induce...
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The Burden of Acute Pesticide Poisoning and Pesticide Regulation in Korea

Ko S, Cha ES, Choi Y, Kim J, Kim JH, Lee WJ

BACKGROUND: This study aimed to estimate the burden of acute pesticide poisoning and to determine its trend with recently implemented pesticide regulations. METHODS: Disability-adjusted life-years (DALYs) were calculated as the sum...
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Effects of Paraquat Ban on Herbicide Poisoning-Related Mortality

Ko DR, Chung SP, You JS, Cho S, Park Y, Chun B, Moon J, Kim H, Kim YH, Kim HJ, Lee KW, Choi S, Park J, Park JS, Kim SW, Seo JY, Park HY, Kim SJ, Kang H, Hong DY, Hong JH

PURPOSE: In Korea, registration of paraquat-containing herbicides was canceled in November 2011, and sales thereof were completely banned in November 2012. We evaluated the effect of the paraquat ban on...
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Predicting the probability of survival in acute paraquat poisoning

Sun IO, Shin SH, Yoon HJ, Lee KY

BACKGROUND: Paraquat (PQ) concentration-time data have been used to predict prognosis for 3 decades. The aim of this study was to find a more accurate method to predict the probability...
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Toxicokinetics of paraquat in Korean patients with acute poisoning

Kim HJ, Kim HK, Lee H, Bae JS, Kown JT, Gil HW, Hong SY

To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit...
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Chest Radiographic Findings in Acute Paraquat Poisoning

Na GG, Lee MS, Noh KH, Kim HJ, Sun IO

PURPOSE: To describe the chest radiographic findings of acute paraquat poisoning. MATERIALS AND METHODS: 691 patients visited the emergency department of our hospital between January 2006 and October 2012 for paraquat...
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Common Pesticides Used in Suicide Attempts Following the 2012 Paraquat Ban in Korea

Lee JW, Hwang IW, Kim JW, Moon HJ, Kim KH, Park S, Gil HW, Hong SY

To determine the change in pesticides used during suicide attempts after the 2012 paraquat (PQ) ban, we evaluated the annual number of suicide attempts by pesticide ingestion between 2011 and...
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Paraquat Induces Apoptosis through a Mitochondria-Dependent Pathway in RAW264.7 Cells

Jang YJ, Won JH, Back MJ, Fu Z, Jang JM, Ha HC, Hong S, Chang M, Kim DK

Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has...
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Homicidal Paraquat Poisoning in Exhumed Case

Park S, Jeong S, Lee HY

Paraquat is a nonselective herbicide, but its lethal and toxic effects are well known. Although its chemical additives have an unpleasant taste, this can be shrouded in spicy foods or...
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Paraquat Induces Apoptosis through Cytochrome C Release and ERK Activation

Seo HJ, Choi SJ, Lee JH

Paraquat has been suggested to induce apoptosis by generation of reactive oxygen species (ROS). However, little is known about the mechanism of paraquat-induced apoptosis. Here, we demonstrate that extracellular signal-regulated...
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Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication

Gil HW, Hong JR, Jang SH, Hong SY

Paraquat (PQ) has known negative human health effects, but continues to be commonly used worldwide as a herbicide. Our clinical data shows that the main prognostic factor is the time...
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Two Successfully Treated Cases of Pulmonary Fibrosis Due to Paraquat Poisoning

Lee WK, Seong CS, Kim BS, Choi HM, Lee HS, Yoon HJ, Kim JG, Lee MS, Lee KY, Sun IO

Paraquat poisoning can cause severe multiple organ failure involving the kidneys, liver, lungs, adrenals, and central nervous system. The toxic effect of paraquat on the lung manifests as pulmonary edema,...
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The dose of cyclophosphamide for treating paraquat-induced rat lung injury

Choi JS, Jou SS, Oh MH, Kim YH, Park MJ, Gil HW, Song HY, Hong SY

BACKGROUND/AIMS: Cyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury. METHODS: Adult male Sprague-Dawley rats...
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Sulforaphane Post-treatment Had No Protective Effects in Paraquat-intoxicated Rats

Jang GS, Lee JH, Kim K, Jo YH, Rhee JE, Lee K, Park CJ, Kang CW, Lee S, Kim J

  • KMID: 2094364
  • J Korean Soc Traumatol.
  • 2013 Mar;26(1):6-13.
PURPOSE: Sulforaphane is a naturally-occurring isothiocyanate abundant in broccoli. It has been suggested as a promising antioxidant. In this study, the therapeutic effect of sulforaphane in paraquat intoxication was investigated. METHODS:...
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Successful Management of Fatal Paraquat Poisoning with Four Courses of Steroid and Cyclophosphamide Pulse

Kim KL, Lee CS, Lee MJ, Kim HS, Choi MJ, Yoon JW, Koo JR

  • KMID: 2263461
  • Korean J Med.
  • 2012 Sep;83(3):373-377.
Although severe paraquat poisoning is fatal, intensive immunosuppression can be successful in selected patients. We report the case of a 33-yr-old patient who was poisoned by paraquat and developed multi-organ...
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The Time between Paraquat Ingestion and a Negative Dithionite Urine Test in an Independent Risk Factor for Death and Organ Failure in Acute Paraquat Intoxication

Seok S, Kim YH, Gil HW, Song HY, Hong SY

To identify a prognostic marker that is less sensitive to variations in the elapsed time since paraquat ingestion, we assessed the time between paraquat ingestion and a negative dithionite urine...
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The Influence of Antioxidant Resveratrol on Paraquat-induced Oxidative Stress in Cultured Lung Cells

Baek KM, Lee SW, Park JS, Min JH, Hwang G, Do H, Kim H

  • KMID: 2333153
  • J Korean Soc Emerg Med.
  • 2012 Aug;23(4):543-550.
PURPOSE: Paraquat (1,1'-dimethy-4,4'-bipyridinium dichloride, PQ) is an effective and widely used herbicide, which was introduced commercially in 1962. It is reduced by an electron donor, such as NADPH, and then...
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Comparative Study Evaluating the Accuracy of the Urine Sodium Dithionite Test to Predict Plasma Paraquat Concentration in Poisoning Cases

Kang IG, Park CS, Ryu HS, Kim HJ, Park SS, Lee MJ, Jeong WJ, Lee WS

  • KMID: 2333041
  • J Korean Soc Emerg Med.
  • 2011 Dec;22(6):696-700.
PURPOSE: Plasma Paraquat level is one of the most important prognostic factors used in identifying Paraquat poisoning. Urine sodium dithionite tests are widely used in clinical settings for detecting the...
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