Korean J Anesthesiol.  2009 Nov;57(5):656-661. 10.4097/kjae.2009.57.5.656.

Malignant hyperthermia during general anesthesia for a surgery of idiopathic scoliosis: A case report

• Kim HY
• Kim YJ

• KMID: 2092258
• DOI: http://doi.org/10.4097/kjae.2009.57.5.656

Abstract

Malignant hyperthermia is a potentially fatal hypermetabolic syndrome characterized by skeletal muscle rigidity and hyperpyrexia. We had an 11-year-old female presented for a surgery for idiopathic scoliosis of the thoracic vertebra. Generalized muscle rigidity and tachycardia were revealed 1 hour 35 minutes after isoflurane administration. Then the body temperature was risen to 43degrees C within 10 minutes and the arterial blood gas analysis showed a severe respiratory and metabolic acidosis. Under the suspicion of malignant hyperthermia, the patient was treated by discontinuing all anesthetic agents, hyperventilation with 100% oxygen, surface cooling with ice pack and the administration of dantrolene sodium. But, the patient died of renal failure and disseminated intravascular coagulation after 50 days postoperatively.

Keyword

Dantrolene sodium; Malignant hyperthermia; Scoliosis

MeSH Terms

Acidosis
Anesthesia, General
Anesthetics
Blood Gas Analysis
Body Temperature
Child
Dantrolene
Disseminated Intravascular Coagulation
Female
Humans
Hyperventilation
Ice
Isoflurane
Malignant Hyperthermia
Muscle Rigidity
Muscle, Skeletal
Oxygen
Renal Insufficiency
Scoliosis
Spine
Tachycardia
Anesthetics
Dantrolene
Ice
Isoflurane
Oxygen