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The optimal model of reperfusion injury in vitro using H9c2 transformed cardiac myoblasts

Son E, Lee D, Woo CW, Kim YH

An in vitro model for ischemia/reperfusion injury has not been well-established. We hypothesized that this failure may be caused by serum deprivation, the use of glutamine-containing media, and absence of...
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Comparison of the trometamol-balanced solution with two other crystalloid solutions for fluid resuscitation of a rat hemorrhagic model

Ting WT, Chang RW, Wang CH, Chen YS, Lee JJ

Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was...
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Proximal renal tubular acidosis with and without Fanconi syndrome

Kashoor I, Batlle D

Proximal renal tubular acidosis (RTA) is caused by a defect in bicarbonate (HCO₃⁻) reabsorption in the kidney proximal convoluted tubule. It usually manifests as normal anion-gap metabolic acidosis due to...
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Use of a trans-tracheal rapid insufflation of oxygen device in a “cannot intubate, cannot oxygenate” scenario in a parturient: a case report

Lee J, Ng VV, Teo C, Wong P

BACKGROUND: The trans-tracheal rapid insufflation of oxygen (TRIO) device is less commonly used and is an alternative to trans-tracheal jet ventilation for maintaining oxygenation in a “cannot intubate, cannot oxygenate”...
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Neurodevelopmental Outcome of Severe Acidemic Term Infants

Chang SH, Hong SH, Hwang IJ, Song ES, Choi YY

OBJECTIVE: This study aimed to evaluate the perinatal factors associated with neonatal mortality and neurologic morbidity in term infants with severe acidosis. METHODS: We retrospectively reviewed the data of term infants...
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A Case of Treatment with QRS Widening in Electrocardiogram after Glyphosate Herbicide Poisoning

Lee JH

Glyphosate herbicides, which are widely used worldwide, are known to have low toxicity. However, excessive intake may cause serious life-threatening complications; therefore, caution is needed when using them. A 51-year-old...
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Twenty-one-year follow-up of variable onset MELAS syndrome with heteroplasmic nt3243A>G mtDNA mutation: A case report

Song WJ, Lee YJ, Kang JW, Chang MY, Song KS, Kang DY, Kim SZ

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder of which m.3243A>G is the most commonly associated mutation, resulting in an inability to meet...
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Transient Blindness in a Patient with Severe Metformin-Associated Lactic Acidosis (MALA)

Jeon JW, Choi W, Kim HR, Ham YR, Choi DE, Na KR, Lee KW, Bae SY, Kim SH

A 68-year-old man presented at the emergency room with sudden blindness. The day before, he had eaten sashimi and eel and drank alcohol for dinner. He experienced nausea, vomiting, and...
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Delta Neutrophil Index is Useful to Predict Poor Outcomes in Male Patients with Alcoholic Ketoacidosis

Kim MK, Shin HW, Kim YJ, Yang JW, Kim JS, Han BG, Choi SO, Lee JY

BACKGROUND: Alcoholic ketoacidosis (AKA) is known as a benign disease, but the related mortality reported in Korea is high. Acidosis and alcohol change the immunity profile, and these changes can...
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Safety and efficacy of peripheral nutrition fluid (MG-TNA®) in patients undergoing surgery for hepatobiliary and pancreatic disease: Results of a phase 4 trial

Yu YD, Han JH, Jung SW, Kim DS

BACKGROUNDS/AIMS: Essential nutritional support and nutrition therapy for patients with hepatobiliary and pancreatic diseases undergoing surgery is critical, as it may improve clinical outcome. How to implement rational fluid therapy...
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A Rare Cause of Life-Threatening Ketoacidosis: Novel Compound Heterozygous OXCT1 Mutations Causing Succinyl-CoA:3-Ketoacid CoA Transferase Deficiency

Kim YA, Kim SH, Cheon CK, Kim YM

Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency is a rare inborn error of ketone body utilization, characterized by episodic or permanent ketosis. SCOT deficiency is caused by mutations in the OXCT1 gene,...
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Resuscitation from a pH of 6.5: A Case Report and Review of Pathophysiology and Management of Extreme Acidosis from Hypovolemic Shock after Trauma

Balmaceda , Arora S, Sondheimer I, Hollon MM

Extreme acidosis is a life-threatening physiological state that causes disturbances in the cardiovascular, pulmonary, immune, and hematological systems. Trauma patients commonly present to the operating room (OR) in hypovolemic shock,...
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Propionic Acidemia with Novel Mutation Presenting as Recurrent Pancreatitis in a Child

Choe JY, Jang KM, Min SY, Hwang SK, Kang B, Choe BH

Propionic acidemia (PA) is a rare organic acidemia resulting from a deficiency of the mitochondrial enzyme propionyl-coenzyme A carboxylase. Most cases are diagnosed after the detection of metabolic abnormalities—such as...
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Acetazolamide-Induced Type II Renal Tubular Acidosis and Muscle Weakness

Bin CH, Kim JH

No abstract available.
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Safety of blood mixture transfusion by rapid infusion device in liver transplantation recipients

Yang SM, Jung CW, Kim WH, Ryu HG, Yoon SB, Lee HC

BACKGROUND: Information on biochemical changes following rapid transfusion of blood mixtures in liver transplantation patients is limited. METHODS: A blood mixture composed of red blood cells, fresh frozen plasma, and 0.9%...
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Successful case of veno-venous extracorporeal membrane oxygenation in an abdominal trauma patient: A case report

Kim JH, Kim JY, Park S

A 37-year-old male visited the hospital with multiple trauma after traffic accident. Fractures of ribs, left femur, and right humerus and spleen rupture with hemoperitoneum were founded on image studies....
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Transient Pseudohypoaldosteronism in a 5-Month-old Infant Manifested as a Failure to Thrive

Lee JW, Cho SJ, Kim HS

Pseudohypoaldosteronism (PHA) in infants is manifested by presence of hyperkalemia, hyponatremia, and metabolic acidosis. At initial stages, PAH is generally suspected as congenital adrenal hyperplasia. Transient PHA has been reported...
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Hypertension secondary to renal hypoplasia presenting as acute heart failure in a newborn

Deitrick J, Stevenson , Nguyen D, Sessions W, Linga V, Vasylyeva

INTRODUCTION: Neonatal hypertension is defined as persistent systolic and/or diastolic blood pressures above the 95th percentile compared to other infants of similar gestational age and size. Neonatal hypertension is a...
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Usefulness of Rotational Thromboelastometry as a Mortality Predictor of Hyperfibrinolysis in Patients with Severe Trauma

Kim JS, Wang IJ, Yeom SR, Cho SJ, Kim JH, Seok JP, Lee SH, Bae BG, Min MK

BACKGROUND: Hemorrhage is the major cause of traumatic death and the leading cause of preventable death. Hyperfibrinolysis is associated with trauma severity. Viscoelastic hemostatic assays show complete clot formation dynamics....
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Validation of critical administration threshold and massive transfusion for mortality prediction in patients with adult severe trauma

Cho JW, Seo KS, Lee MJ, Park JB, Kim JK, Ryoo HW, Ahn JY, Moon S, Lee DE, Kim YJ, Choe JY

OBJECTIVE: A massive transfusion (MT) of 10 or more units of packed red blood cells (PRCs) focuses on the summation volumes over 24 hours. This traditional concept promotes survivor bias...
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