Korean J Hematol.  2008 Sep;43(3):170-173. 10.5045/kjh.2008.43.3.170.

A Case of Acute Lymphoblastic Leukemia Accompanied with Lactic Acidosis and Kidney Enlargement

  • 1Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. mlee@kuh.ac.kr


There have been several reported cases of acute lymphoblastic leukemia with severe lactic acidosis in adults. In these cases, kidney and liver enlargement that was caused by leukemic infiltration frequently accompanied the acute lymphoblastic leukemia and severe lactic acidosis. Chemotherapy is the only treatment that can rapidly correct the lactic acidosis and normalize the liver and kidney enlargement. We report here on a case of acute lymphoblastic leukemia that was accompanied with severe lactic acidosis and kidney enlargement.


Acute lymphoblastic leukemia; Lactic acidosis; Leukemic infiltration; Kidney enlargement; Liver enlargement

MeSH Terms

Acidosis, Lactic
Leukemic Infiltration
Precursor Cell Lymphoblastic Leukemia-Lymphoma


  • Fig. 1 Initial abdominal CT. Abdominal CT reveals diffuse parenchymal swelling of both kidneys.

  • Fig. 2 Changes of bicarbonate and lactic acid. Graph reveals changes of lactic acid & bicarbonate level after hemodialysis (HD #5) & chemotherapy (HD #8).

  • Fig. 3 Abdominal CT after chemotherapy. Abdominal CT after chemotherapy reveals normalization in the size of both kidneys.


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