Korean J Hematol.  2008 Sep;43(3):170-173. 10.5045/kjh.2008.43.3.170.

A Case of Acute Lymphoblastic Leukemia Accompanied with Lactic Acidosis and Kidney Enlargement

• Cho HS
• Choi SO
• Seol DC
• Yoon HS
• Jo YI
• Lee HG

• KMID: 2252184
• DOI: http://doi.org/10.5045/kjh.2008.43.3.170

Abstract

There have been several reported cases of acute lymphoblastic leukemia with severe lactic acidosis in adults. In these cases, kidney and liver enlargement that was caused by leukemic infiltration frequently accompanied the acute lymphoblastic leukemia and severe lactic acidosis. Chemotherapy is the only treatment that can rapidly correct the lactic acidosis and normalize the liver and kidney enlargement. We report here on a case of acute lymphoblastic leukemia that was accompanied with severe lactic acidosis and kidney enlargement.

Keyword

Acute lymphoblastic leukemia; Lactic acidosis; Leukemic infiltration; Kidney enlargement; Liver enlargement

MeSH Terms

Acidosis, Lactic
Adult
Humans
Kidney
Leukemic Infiltration
Liver
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Figure

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  Fig. 1 Initial abdominal CT. Abdominal CT reveals diffuse parenchymal swelling of both kidneys.

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  Fig. 2 Changes of bicarbonate and lactic acid. Graph reveals changes of lactic acid & bicarbonate level after hemodialysis (HD #5) & chemotherapy (HD #8).

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  Fig. 3 Abdominal CT after chemotherapy. Abdominal CT after chemotherapy reveals normalization in the size of both kidneys.

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