Korean J Nephrol.  2009 Jan;28(1):41-43.

A Case of Lactic Acidosis Associated with Prolonged Linezolid Therapy

Affiliations
  • 1Department of Internal Medicine, College of Medicine Soon Chun Hyang University, Seoul, Korea. jeonjs@hosp.sch.ac.kr

Abstract

Lactic acidosis is the most common cause of metabolic acidosis in hospitalized patients. Although impaired tissue oxygenation is usually responsible for the rise in lactate production, lactic acidosis could be caused by drugs including metformin and the nucleoside reverse-transcriptase inhibitors. Linezolid, an oxazolidinone antibiotic, is currently indicated to treat serious infections caused by vancomycin-resistant enterococcus and other gram-positive organisms. A 74-year old woman was found to have pyogenic vertebral osteomyelitis and treated with linezolid. Thirty-one days after linezolid therapy, she developed severe lactic acidosis. We report a case of lactic acidosis associated with prolonged linezolid therapy.

Keyword

Linezolid; Lactic acidosis

MeSH Terms

Acetamides
Acidosis
Acidosis, Lactic
Enterococcus
Female
Humans
Lactic Acid
Metformin
Osteomyelitis
Oxazolidinones
Oxygen
Linezolid
Acetamides
Lactic Acid
Metformin
Oxazolidinones
Oxygen
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