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Emergence of optrA-Mediated Linezolid-Nonsusceptible Enterococcus faecalis in a Tertiary Care Hospital

Park K, Jeong YS, Chang J, Sung H, Kim MN

This study investigated resistance mechanisms and epidemiology of emerging linezolid-nonsusceptible Enterococcus faecalis (LNSEF) in a tertiary care hospital. LNSEF isolated from clinical samples were collected from November 2017 to June...
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Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus in Korea: High Rate of False Resistance to Linezolid by the VITEK 2 System

Yoo IY, Kang OK, Shim HJ, Huh HJ, Lee NY

As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK...
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Optic Neuropathy after Taking Linezolid

Yoon YS, Lee CK

PURPOSE: We report a case of optic neuropathy in a patient who was treated with pre-extensively drug-resistant tuberculosis(pre-XDR TB) treatment with linezolid. CASE SUMMARY: A 61-year-old male patient with no other...
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Molecular Epidemiology and Mechanisms of 43 Low-Level Linezolid-Resistant Enterococcus faecalis Strains in Chongqing, China

Hua R, Xia Y, Wu W, Yang M, Yan J

BACKGROUND: Enterococcus faecalis strains with low-level resistance to linezolid (an oxazolidinone antibiotic) have become common. No large-scale study has examined the underlying mechanisms in linezolid-resistant E. faecalis (LRE) strains. We...
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Delamanid, Bedaquiline, and Linezolid Minimum Inhibitory Concentration Distributions and Resistance-related Gene Mutations in Multidrug-resistant and Extensively Drug-resistant Tuberculosis in Korea

Yang JS, Kim KJ, Choi H, Lee SH

BACKGROUND: Delamanid, bedaquiline, and linezolid have recently been approved for the treatment of multidrug- and extensively drug-resistant (MDR and XDR, respectively) tuberculosis (TB). To use these drugs effectively, drug susceptibility...
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Efficacy and Tolerability of Linezolid for Treatment of Infectious Spondylitis

Jung J, Lee E, Song KH, Choe PG, Park WB, Bang JH, Kim ES, Kim HB, Park SW, Kim NJ, Oh MD

BACKGROUND/AIMS: Infectious spondylitis requires long-term antibiotic treatment; however, the use of intravenous antibiotics during this period has high social and monetary costs due to hospitalization. Linezolid has high oral bioavailability...
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Brain Abscess Showing a Lack of Restricted Diffusion and Successfully Treated with Linezolid

Kim JH, Park SP, Moon BG, Kim DR

A 59-year-old patient with a history of hepatocellular carcinoma presented with decreased consciousness and left hemiparesis. A rim-enhanced mass lesion without diffusion restriction was observed in contrast-enhanced MRI including diffusion-weighted...
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Healthcare-associated Endocarditis by PVL-negative ST 72 SCCmec Type IV MRSA

Oh HM, Kim KU, Park SY, Lee JS, Kim JS, Eom JS

The prevalence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been increasing worldwide. In Korea, the most common genotype of CA-MRSA is the Panton-Valentine leukocidin-negative, sequence type 72 Staphylococcal cassette chromosome...
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Outcomes and Use of Therapeutic Drug Monitoring in Multidrug-Resistant Tuberculosis Patients Treated in Virginia, 2009-2014

Heysell SK, Moore JL, Peloquin C, Ashkin D, Houpt ER

BACKGROUND: Reports of therapeutic drug monitoring (TDM) for second-line medications to treat multidrug-resistant tuberculosis (MDR-TB) remain limited. METHODS: A retrospective cohort from the Virginia state tuberculosis (TB) registry, 2009-2014, was analyzed...
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Serotonin syndrome associated with linezolid

Jeon DS, Nam YH, Kim SH, Choi WJ, Kim EB, Lee HW, Nam HJ, Song JE, Lee SK

Serotonin syndrome (SS) is a potentially life-threatening drug reaction characterized by mental status change, increased neuromuscular tone, and autonomic instability. Linezolid, an oxazolidinone antibacterial agent, is widely used in general...
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Susceptibility of Glycopeptide-Resistant Enterococci to Linezolid, Quinupristin/dalfopristin, Tigecycline and Daptomycin in a Tertiary Greek Hospital

Maraki S, Samonis G, Dimopoulou D, Mantadakis E

We investigated the antibiotic susceptibility of glycopeptide-resistant enterococci (GRE). Seventy consecutive GRE were tested. Sixty-two isolates were identified as Enterococcus faecium (88.6%), and 8 (11.4%) as Enterococcus faecalis. All strains...
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Recent Advances in Tuberculosis and Nontuberculous Mycobacteria Lung Disease

Park JS

  • KMID: 2320424
  • Tuberc Respir Dis.
  • 2013 Jun;74(6):251-255.
Tuberculosis (TB) is one of the largest health problems in the world today. And the incidence of nontuberculous mycobacteria (NTM) lung disease appears to be increasing worldwide. Recently, an automated,...
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A Case of Lactic Acidosis Caused by Linezolid Treatment of Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia

Kim YS, Kim JB, Lee Y, Kim SH, Choi SH, Woo JH, Kim YS

  • KMID: 2264306
  • Korean J Med.
  • 2012 Apr;82(4):512-515.
Linezolid is an antibiotic in the oxazolidinone family that works as a bacterial protein synthesis inhibitor. It is used for the treatment of Gram-positive, multidrug-resistant bacteria. Adverse effects of linezolid...
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A Case of Linezolid-Associated Lactic Acidosis

Lee HJ, Choi JH, Kim SY, Chung KH, Lee TW, Ihm CG, Moon JY

  • KMID: 2264256
  • Korean J Med.
  • 2012 Mar;82(3):371-373.
Linezolid has been used for treatment of vancomycin-resistant Enterococcus faecium infection, nosocomial pneumonia caused by Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus or Streptococcus pneumoniae, and complicated and uncomplicated skin and...
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A Case of Septic Arthritis Caused by Persistent MRSA Bacteremia with Successful Treatment Through Linezolid

Kim SB, Oh DH, Kim YC, Kim MH, Song JE, Ahn JY, Jeong SJ, Goo NS, Kim HW, Han SH, Choi JY, Song YG, Kim JM

Vancomycin is the primary antibiotic administered for treatment of methicillin-resistant S. aureus (MRSA) infection; however, treatment failure of vancomycin is currently not uncommon in patients with in vitro vancomycin susceptibile...
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Vancomycin-Resistant Enterococcus faecium Meningitis Treated with Linezolid: A Case Report and Review of the Literature

Lee CS, Park SJ, Lee YC, Rhee YK, Lee HB

Vancomycin-resistant enterococci (VRE) infection is a serious problem because optimal therapy has not been established. Different agents in various combinations, including teicoplanin, chloramphenicol, and quinupristin/dalfopristin, have been used to treat...
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Successful Treatment of Recurrent Methicillin-resistant Staphylococcus aureus Bacteremia and Endocarditis by Linezolid, Valve Replacement, and Excisional Surgery of Limb in a Patient with Complicated Arteriovenous Malformation

Lee K, Kim H, Kim J, Lee G, Lee H, Kim H, Kim D, Sohn I, Pai H

Vancomycin treatment failure in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia patients has increased over the past decade. We experienced a case of repeated MRSA bacteremia resulting in left-side endocarditis in 38-year-old...
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Postoperative Meningitis in Patients with Cervical Cord Tumor: A Case Report

Kawaguchi , Seki S, Yasuda T, Nakamura Y, Nakano M, Kimura T

Postoperative meningitis after spinal surgery is a rare complication that can result in a life-threatening condition. Linezolid (LZD) is an oxazolidinone which has been approved in Japan for infections caused...
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Alternating Linezolid-Vancomycin Therapy for Persistent Endovascular Methicillin-resistant Staphylococcus aureus Infection: A Case Report

Kim NH, Kim M, Jang ES, Kang YM, Kim G, Jang HC, Park WB, Kim EC, Kim NJ, Oh MD

Persistent Staphylococcus aureus bacteremia is frequently defined as bacteremia persisting for > or =7 days despite proper antibiotic therapy. Its treatment includes removal of all infection foci and proper antibiotic...
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A Case of Lactic Acidosis Associated with Prolonged Linezolid Therapy

Chung SK, Jeon JS, Kim TH, Kim C, Kwon SH, Noh HJ, Han DC

  • KMID: 2253204
  • Korean J Nephrol.
  • 2009 Jan;28(1):41-43.
Lactic acidosis is the most common cause of metabolic acidosis in hospitalized patients. Although impaired tissue oxygenation is usually responsible for the rise in lactate production, lactic acidosis could be...
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