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Emergence of optrA-Mediated Linezolid-Nonsusceptible Enterococcus faecalis in a Tertiary Care Hospital

Park K, Jeong YS, Chang J, Sung H, Kim MN

This study investigated resistance mechanisms and epidemiology of emerging linezolid-nonsusceptible Enterococcus faecalis (LNSEF) in a tertiary care hospital. LNSEF isolated from clinical samples were collected from November 2017 to June...
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Culture-Positive Spontaneous Ascitic Infection in Patients with Acute Decompensated Cirrhosis: Multidrug-Resistant Pathogens and Antibiotic Strategies

Liu J, Gao Y, Wang X, Qian Z, Chen J, Huang Y, Meng Z, Lu X, Deng G, Liu F, Zhang Z, Li H, Zheng X

PURPOSE: This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of culture-positive spontaneous ascitic infection (SAI) in patients with acute decompensated cirrhosis. MATERIALS AND METHODS: We retrospectively analyzed 432 acute decompensated...
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Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus in Korea: High Rate of False Resistance to Linezolid by the VITEK 2 System

Yoo IY, Kang OK, Shim HJ, Huh HJ, Lee NY

As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK...
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Treatment of Mycobacterium Abscessus Pulmonary Disease

Jhun BW, Koh WJ

Mycobacterium abscessus is the second most important pathogen in pulmonary disease caused by nontuberculous mycobacteria (NTM), following Mycobacterium avium. Mycobacterium abscessus is classified into three subspecies: M. abscessus subsp. abscessus,...
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The First Case of Otitis in Korea Caused by Brevibacterium otitidis

Mun SH, Lee AJ, Kim SG, Jeon CH, Park CG, Suh HS

Brevibacterium spp. are gram-positive rods that are considered to be strictly nonpathogenic, and a very few cases of their infection in humans have been reported. In this study, we report...
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Multiplex PCR analysis of virulence genes and their influence on antibiotic resistance in Enterococcus spp. isolated from broiler chicken

Song H, Bae Y, Jeon E, Kwon Y, Joh S

Enterococcus spp. are opportunistic pathogens that cause lameness in broiler chickens, resulting in serious economic losses worldwide. Virulence of Enterococcus spp. is associated with several putative virulence genes including fsr,...
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A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States

Lee DH, Klinkova O, Kim JW, Nanjappa S, Greene JN

BACKGROUND: Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CoNS) that is a part of the normal human skin flora. Even though it belongs to CoNS family, it can cause severe and...
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Optic Neuropathy after Taking Linezolid

Yoon YS, Lee CK

PURPOSE: We report a case of optic neuropathy in a patient who was treated with pre-extensively drug-resistant tuberculosis(pre-XDR TB) treatment with linezolid. CASE SUMMARY: A 61-year-old male patient with no other...
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Evaluation of in vitro antimicrobial susceptibility of Bacillus anthracis strains isolated during anthrax outbreaks in Italy from 1984 to 2017

Manzulli V, Fasanella , Parisi A, Serrecchia L, Donatiello A, Rondinone , Caruso M, Zange S, Tscherne A, Decaro N, Pedarra C, Galante D

Anthrax, caused by Bacillus anthracis, is a non-contagious infectious disease that affects a wide range of animal species (primarily ruminants) including humans. Due to the often-fatal outcome in humans, quick...
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Molecular Epidemiology and Mechanisms of 43 Low-Level Linezolid-Resistant Enterococcus faecalis Strains in Chongqing, China

Hua R, Xia Y, Wu W, Yang M, Yan J

BACKGROUND: Enterococcus faecalis strains with low-level resistance to linezolid (an oxazolidinone antibiotic) have become common. No large-scale study has examined the underlying mechanisms in linezolid-resistant E. faecalis (LRE) strains. We...
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Microbiological Characteristics of Corynebacterium striatum, an Emerging Pathogen

Song SA, Shin JH

C. striatum is part of the normal skin and mucous membrane flora in humans and is widely disseminated in the environment. Traditionally, these strains have been considered contaminants. However, C....
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Antimicrobial therapy for methicillin-resistant Staphylococcus aureus

Choo EJ

Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of healthcare-associated infections. Recently, community-associated MRSA has emerged, manifesting as skin and soft tissue infections in patients without any prior healthcare contact....
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Delamanid, Bedaquiline, and Linezolid Minimum Inhibitory Concentration Distributions and Resistance-related Gene Mutations in Multidrug-resistant and Extensively Drug-resistant Tuberculosis in Korea

Yang JS, Kim KJ, Choi H, Lee SH

BACKGROUND: Delamanid, bedaquiline, and linezolid have recently been approved for the treatment of multidrug- and extensively drug-resistant (MDR and XDR, respectively) tuberculosis (TB). To use these drugs effectively, drug susceptibility...
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Efficacy and Tolerability of Linezolid for Treatment of Infectious Spondylitis

Jung J, Lee E, Song KH, Choe PG, Park WB, Bang JH, Kim ES, Kim HB, Park SW, Kim NJ, Oh MD

BACKGROUND/AIMS: Infectious spondylitis requires long-term antibiotic treatment; however, the use of intravenous antibiotics during this period has high social and monetary costs due to hospitalization. Linezolid has high oral bioavailability...
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Brain Abscess Showing a Lack of Restricted Diffusion and Successfully Treated with Linezolid

Kim JH, Park SP, Moon BG, Kim DR

A 59-year-old patient with a history of hepatocellular carcinoma presented with decreased consciousness and left hemiparesis. A rim-enhanced mass lesion without diffusion restriction was observed in contrast-enhanced MRI including diffusion-weighted...
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High Incidence of Virulence Factors Among Clinical Enterococcus faecalis Isolates in Southwestern Iran

Heidari H, Hasanpour , Ebrahim-Saraie HS, Motamedifar M

BACKGROUND: Over the past two decades, enterococci have emerged as an important agent responsible for hospital acquired infection. Several virulence factors contribute to the adherence, colonization, evasion of the host...
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Management of Antibiotic-Resistant Acute Pyelonephritis

Lee HN, Yoon H

Acute pyelonephritis (APN) is a common urinary tract infection that affects a large proportion of women. Although antimicrobial therapy is a successful treatment in most cases, empirically, antibiotic resistance has...
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Healthcare-associated Endocarditis by PVL-negative ST 72 SCCmec Type IV MRSA

Oh HM, Kim KU, Park SY, Lee JS, Kim JS, Eom JS

The prevalence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been increasing worldwide. In Korea, the most common genotype of CA-MRSA is the Panton-Valentine leukocidin-negative, sequence type 72 Staphylococcal cassette chromosome...
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A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain

Jung EK, Chang JY, Lee YP, Chung MK, Seo EK, Koo HS, Choi HJ

We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin....
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Molecular Typing and Resistance Profiles of Vancomycin-Intermediate Staphylococcus aureus in Korea: Results from a National Surveillance Study, 2007-2013

Kim JW, Kang GS, Yoo JI, Kim HS, Lee YS, Yu JY, Lee KJ, Park C, Kim IH

BACKGROUND: To investigate the national molecular epidemiology and resistance profiles of vancomycin-intermediate Staphylococcus aureus (VISA), we analyzed the characteristics of methicillin-resistant Staphylococcus aureus (MRSA) collected from clinical samples at tertiary...
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