Infect Chemother.  2012 Oct;44(5):403-406. 10.3947/ic.2012.44.5.403.

A Case of Septic Arthritis Caused by Persistent MRSA Bacteremia with Successful Treatment Through Linezolid

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. shhan74@yuhs.ac
  • 2AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Vancomycin is the primary antibiotic administered for treatment of methicillin-resistant S. aureus (MRSA) infection; however, treatment failure of vancomycin is currently not uncommon in patients with in vitro vancomycin susceptibile S. aureus (MIC < or = 2 microg/mL) infection. In this report, we describe a case of septic arthritis caused by persistent MRSA bacteremia and treated successfully with linezolid after failure of initial vancomycin therapy.

Keyword

Methicillin-Resistant Staphylococcus aureus; Bacteremia; Infectious arthritis; Vancomycin; Linezolid

MeSH Terms

Acetamides
Arthritis, Infectious
Bacteremia
Humans
Linezolid
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Oxazolidinones
Treatment Failure
Vancomycin
Acetamides
Oxazolidinones
Vancomycin

Figure

  • Figure 1 Whole body bone scan after intravenous injection of Tc-99m HDP. Increased uptake in the left knee is suggestive of arthritis. Right ilium, superior and inferior pubic rami also show increased uptake, which is compatible with known multiple pelvic bone fracture.

  • Figure 2 Contrast-enhanced, fat-suppressed T1 weighted magnetic resonance imaging (MRI) of the left knee. (A) MRI shows synovial enhancement, joint effusion, and diffuse soft-tissue edema suggestive of septic arthritis. (B) Synovial enhancement, effusion, and edema showed significant improvement after 32 days of treatment with linezolid.


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