Infect Chemother.  2010 Jun;42(3):194-197. 10.3947/ic.2010.42.3.194.

Vancomycin-Resistant Enterococcus faecium Meningitis Treated with Linezolid: A Case Report and Review of the Literature

Affiliations
  • 1Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, Korea. lhbmd@chonbuk.ac.kr

Abstract

Vancomycin-resistant enterococci (VRE) infection is a serious problem because optimal therapy has not been established. Different agents in various combinations, including teicoplanin, chloramphenicol, and quinupristin/dalfopristin, have been used to treat patients with VRE meningitis, but the efficacy of these agents is not satisfactory because of their limited ability to penetrate into the cerebrospinal fluid. We report a case of nosocomial vancomycin-resistant Enterococcus faecium meningitis in a patient with ventriculoperitoneal shunt that was successfully treated with linezolid. We will also review previously reported cases of vancomycin-resistant E. faecium meningitis treated by linezolid.

Keyword

Vancomycin; Enterococcus faecium; Meningitis; Linezolid

MeSH Terms

Acetamides
Chloramphenicol
Enterococcus
Enterococcus faecium
Humans
Linezolid
Meningitis
Oxazolidinones
Teicoplanin
Vancomycin
Ventriculoperitoneal Shunt
Acetamides
Chloramphenicol
Oxazolidinones
Teicoplanin
Vancomycin
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