Korean J Anesthesiol.  1990 Aug;23(4):543-548. 10.4097/kjae.1990.23.4.543.

Experimental Study of Barbiturates on Cerebral Protective Action with a Rat Forebrain Ischemic Model

• Kwon JY
• Kim SS
• Baik SW
• Kim IS
• Chung KS

• KMID: 2090552
• DOI: http://doi.org/10.4097/kjae.1990.23.4.543

Abstract

The pathologic effects of barbiturates on cerebral ischemia were investigated in 40 male rats. Twenty animals given intravenous thiopental (4 mg/kg) before 10-minute occlusion of both common carotid arteries with mean arterial pressure of 50 mmHg were compared to 20 control animals which were not treated with thiopental. 1) There were no significant statistical differences in body weight, body temperature and mean arterial pressure between the two groups. 2) The experimental group treated with barbiturates showed a significant decrease in neuronal damage at the hippocampus CA 1 area (p<0.0001). From the above results, barbiturates are effective in preventing damage of the nervous tissue during brain ischemia.

Keyword

Barbiturates; Brain ischemia; Neuronal damage; Hippocampus

MeSH Terms

Animals
Arterial Pressure
Barbiturates*
Body Temperature
Body Weight
Brain Ischemia
Carotid Artery, Common
Hippocampus
Humans
Male
Neurons
Prosencephalon*
Rats*
Thiopental
Barbiturates
Thiopental