Korean J Anesthesiol.
1990 Aug;23(4):529-535. 10.4097/kjae.1990.23.4.529.
Experimental Study of Cerebral Protective Action with Dexamethasone in a Rat`s Forebrain Ischemic Model
- Affiliations
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- 1Department of Anesthesiology, College of Medicine, Pusan National University, Korea.
- KMID: 2090550
- DOI: http://doi.org/10.4097/kjae.1990.23.4.529
Abstract
- This study examined the protective effect of dexamethansone following bilateral forebrain ischemia in a rat model of two-vessel occlusion. Twenty rats were subjected to dexamethasone (1 mg/kg intravenously) before bilateral common carotid artery occlusion for 10 minutes. Carotid artery blood flow was restored and the rats were terminated by a perfusion-fixation method after 7 days. Ten minutes of two-vessel occlusion produced cellular ischemic change in the cerebral hemispheres of most rats. This region was studied mainly with light microscope, and it was noticed that the CA 1 neuron in the hippocampus is the most vulnerable to ischemia. Ischemic neuronal damage was graded in accordance with conventional neuropathological criteria. The grade had no statistical significance.
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