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The Usefulness of Symptom-based Subtypes of Functional Dyspepsia for Predicting Underlying Pathophysiologic Mechanisms and Choosing Appropriate Therapeutic Agents

Lee KJ

  • KMID: 2517526
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):326-336.
  • doi: 10.5056/jnm21042
Functional dyspepsia (FD) is considered to be a heterogeneous disorder with different pathophysiological mechanisms or pathogenetic factors. In addition to traditional mechanisms, novel concepts regarding pathophysiologic mechanisms of FD have...
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Pathophysiology of neuropathic pain

Kwon O

Background: Neuropathic pain is notoriously difficult to manage properly, not only because of its varied nature and the absence of objective diagnostic tools but also because of extensive reciprocal neuronal...
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Current status of breast implantassociated anaplastic large cell lymphoma in South Korea

Yoon ES

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a unique type of lymphoma caused by breast implants. Concerns about BIA-ALCL have increased worldwide, and three domestic cases have been reported...
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Early menarche and its consequence in Korean female: reducing fructose intake could be one solution

Kim JH, Lim JS

The mean age at menarche (AAM) of Korean females has been rapidly decreasing over the last 50 years; currently, the prevalence of early menarche (
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Neuropathic Pain: How to Assess and Treat a Maladaptive Pain Response

Roh YH

Neuropathic pain is associated with primary lesion or dysfunction of the peripheral and central nerve systems, affecting up to 10% of the general population. Although both nociceptive pain and neuropathic...
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AL amyloidosis: advances in diagnosis and management

Koh Y

Light chain (AL) amyloidosis is a disease in which malignant plasma cell clones affect multiple organs including the heart and kidney. The mechanism for organ function deterioration in AL amyloidosis...
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Sepsis-induced cardiac dysfunction: a review of pathophysiology

Habimana R, Choi I, Cho HJ, Kim D, Lee K, Jeong I

It is well known that cardiac dysfunction in sepsis is associated with significantly increased mortality. The pathophysiology of sepsis-induced cardiac dysfunction can be summarized as involving impaired myocardial circulation, direct...
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Electrognostic findings ofGuillain-Barré syndrome

Yoon BA, Bae JS, Kim JK

The electrodiagnostic findings in Guillain-Barré syndrome (GBS) play important roles in both understanding its pathophysiology and its diagnosis. Only demyelinating neuropathies were thought to be present when GBS patients were first diagnosed...
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The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Low Tone Sensorineural Hearing Loss

Kim KH, Kim BH, Lee S, Chung JH, Byun H, Lee SH

Background and Objectives Acute low tone sensorineural hearing loss (ALHL), an acuteonset hearing loss limited to low tone, was thought to be a subtype of sudden sensorineural hearing loss (SSNHL)...
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Heart Failure with Preserved Ejection Fraction: the Major Unmet Need in Cardiology

Shim CY

Heart failure with preserved ejection fraction (HFpEF) has recently been recognized as the single greatest unmet need in cardiovascular medicine. As the population ages and the comorbidity increases, the prevalence...
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Lumbar Spinal Stenosis: Pathophysiology and Treatment Principle: A Narrative Review

Lee BH, Moon SH, Suk KS, Kim HS, Yang JH, Lee HM

Patients with lumbar spinal stenosis may exhibit symptoms such as back pain, radiating pain, and neurogenic claudication. Although long-term outcome of treatments manifests similar results for both nonsurgical and surgical...
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Molecular Pathophysiology of Ossification of the Posterior Longitudinal Ligament (OPLL)

Nam DC, Lee HJ, Lee CJ, Hwang SC

Ossification of the posterior longitudinal ligament (OPLL) can be defined as an ectopic ossification in the tissues of spinal ligament showing a hyperostotic condition. OPLL is developed mostly in the...
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Defective Conduction of Anorectal Afferents Is a Very Prevalent Pathophysiological Factor Associated to Fecal Incontinence in Women

Mundet L, Cabib C, Ortega O, Rofes L, Tomsen N, Marin S, Chacón C, Clavé P

  • KMID: 2454641
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):423-435.
  • doi: 10.5056/jnm18196
BACKGROUND/AIMS: Fecal incontinence (FI) is a prevalent condition among women. While biomechanical motor components have been thoroughly researched, anorectal sensory aspects are less known. We studied the pathophysiology of FI...
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Emerging Therapies in Chronic Spontaneous Urticaria

Min TK, Saini SS

Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist for longer than 6 weeks. This term is applied to...
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Pharmacologic therapy for nonalcoholic steatohepatitis focusing on pathophysiology

Yoon IC, Eun JR

The paradigm of chronic liver diseases has been shifting. Although hepatitis B and C viral infections are still the main causes of liver cirrhosis and hepatocellular carcinoma (HCC), the introduction...
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Gastroparesis and Functional Dyspepsia: A Blurring Distinction of Pathophysiology and Treatment

Kim BJ, Kuo B

  • KMID: 2433495
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):27-35.
  • doi: 10.5056/jnm18162
Gastroparesis and functional dyspepsia are 2 of the most common gastric neuromuscular disorders. These disorders are usually confused, having both similarities and differences. The pathophysiology of these disorders involves abnormal...
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New Pathophysiological Considerations on Cerebral Aneurysms

Jung KH

Cerebral aneurysm is a common cerebrovascular disease that is sometimes complicated by rupture or an enlarged mass. We are now aggressively evaluating and managing unruptured cerebral aneurysms based on a...
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Delayed paresthesia of inferior alveolar nerve after dental surgery: case report and related pathophysiology

Doh RM, Shin S, You TM

Paresthesia is an altered sensation of the skin, manifesting as numbness, partial loss of local sensitivity, burning, or tingling. The inferior alveolar nerve (IAN) is the third branch of the...
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Pathophysiology and Diagnosis in Atrial Fibrillation

Shin SY

Atrial fibrillation is association a wide range of genetic, metabolic, and environmental causes. The number of patients with atrial fibrillation is increasing exponentially, predominantly due to aging and a variety...
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Epileptic Spasms, a Journey to Find Therapeutics Based on Pathophysiology

Yum MS

After the first description of infantile spasms (IS) in 1841, extensive clinical and laboratory investigations have been done to find the pathophysiology and the optimal treatments. The concept of the...
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