Mycobiology.
2012 Jun;40(2):142-144. 10.5941/MYCO.2012.40.2.142.
Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus
- Affiliations
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- 1Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 570-752, Korea. bsyun@jbnu.ac.kr
- 2National Institute of Agricultural Science and Technology, Rural Development Administration, Suwon 441-707, Korea.
- KMID: 2052905
- DOI: http://doi.org/10.5941/MYCO.2012.40.2.142
Abstract
- During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to 1H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC50 values of 13.1 and 0.03 microM, respectively.
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