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Comparison of In Vivo Pharmacokinetics and Pharmacodynamics of Vancomycin Products Available in Korea

Kim HK, Choi SM, Kang G, Park KH, Lee DG, Park WB, Rhee SJ, Lee S, Jung SI, Jang HC

PURPOSE: Few studies have been investigated the in vivo efficacy of generic vancomycin products available outside of the United States. In this study, we aimed to compare the in vivo...
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Development of an Indirect ELISA Featuring Plates Coated with Column Chromatographically Purified Canine Adenovirus Type-1 Antigen

Yang DK, Kim HH, Lee S, Ji M, Han BH, Oh S, Hyun BH

Canine adenovirus type 1 (CAV-1) causes infectious hepatitis in members of the family Canidae, including dogs. An indirect enzyme-linked immunosorbent assay (I-ELISA) that detects CAV-1 antibodies is required for large-throughput...
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Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant

Park YM, Lee SY, Kang MJ, Kim BS, Lee MJ, Jung SS, Yoon JS, Cho HJ, Lee E, Yang SI, Seo JH, Kim HB, Suh DI, Shin YH, Kim KW, Ahn K, Hong SJ

PURPOSE: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and...
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Isolation and Quantitative Analysis of BACE1 Inhibitory Compounds from Cirsium maackii Flower

Bhatarrai , Seong SH, Jung HA, Choi JS

The purpose of our study was to evaluate anti-AD potential of Cirsium maackii flowers. MeOH extract, CH2Cl2, EtOAc, and n-BuOH fraction of this flower notably inhibited BACE1 (ICâ‚…â‚€ = 76.47...
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Splenocyte-mediated immune enhancing activity of Sargassum horneri extracts

Kim DS, Sung NY, Han IJ, Lee BS, Park SY, Nho EY, Eom J, Kim G, Kim KA

PURPOSE: This study examined the immunological activity and optimized the mixture conditions of Sargassum horneri (S. horneri) extracts in vitro and in vivo models. METHODS: S. horneri was extracted using three...
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Changes in the constituents and UV-photoprotective activity of Astragalus membranaceus caused by roasting

Park JY, Lee JY, Kim HD, Jang GY, Seo KH

PURPOSE: Astragalus membranaceus (AM) is an important traditional medicinal herb. Pharmacological research has indicated that AM has various physiological activities such as antioxidant, anti-inflammatory, immunoregulatory, anticancer, hypolipidemic, antihyperglycemic, and hepatoprotective...
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Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study

Burr RL, Gu H, Cain K, Djukovic D, Zhang X, Han C, Callan N, Raftery D, Heitkemper M

  • KMID: 2460485
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):551-562.
  • doi: 10.5056/jnm19042
BACKGROUND/AIMS: Patients with irritable bowel syndrome (IBS) often report poor sleep quality. Whether poor sleep is associated with tryptophan (Trp) metabolites is unknown. We compared serum Trp metabolites in women...
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Melandrium firmum Extract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice

Huang B, Kang BG, Lim SS, Zhang XH

BACKGROUND: In our preliminary study, we screened for their potential to inhibit 5α-reductase, and Melandrium firmum (MF) extract showed the most potent activity as confirmed by high-performance liquid chromatography (HPLC). OBJECTIVE:...
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Antifungal Activities of Streptomyces blastmyceticus Strain 12-6 Against Plant Pathogenic Fungi

Kim YJ, Kim JH, Rho JY

Streptomyces blastmyceticus strain 12-6 was isolated from a forest soil sample of Cheonan area on the basis of strong antifungal activities against plant pathogenic fungi. Butanol extracts of the cultural...
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Biosynthetic Pathway of Indole-3-Acetic Acid in Basidiomycetous Yeast Rhodosporidiobolus fluvialis

Bunsangiam S, Sakpuntoon V, Srisuk N, Ohashi T, Fujiyama K, Limtong S

IAA biosynthetic pathways in a basidiomycetous yeast, Rhodosporidiobolus fluvialis DMKU-CP293, were investigated. The yeast strain showed tryptophan (Trp)-dependent IAA biosynthesis when grown in tryptophan supplemented mineral salt medium. Gas chromatography–mass...
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Phytochemical Constituents of the Root Bark from Morus alba and Their Il-6 Inhibitory Activity

Chang YS, Jin HG, Lee H, Lee DS, Woo ER

Morus alba L., known as white mulberry, is a medicinal plant belongs to family Moraceae. It has long been used commonly in Ayurvedic for the treatment of lung-heat, cough, asthma,...
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Quantification of the Bioactive Components of the Rhizomes of Curcuma wenyujin and Assessment of Its Anti-inflammatory Effect in Benign Prostatic Hyperplasia-1 Cells

Seo CS, Park E, Lee MY, Shin HK

In this study, the marker compounds of Curcumae Rhizoma (CR) were simultaneously quantified by high-performance liquid chromatography equipped with a photodiode array detector and the anti-inflammatory effects of CR extract...
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Assessment of the Purity of Emodin by Quantitative Nuclear Magnetic Resonance Spectroscopy and Mass Balance

Park S, Choi YJ, Do GH, Seo EK, Hyun S, Lee D

Quantitative nuclear magnetic resonance (qNMR) is a well-established method adopted by international pharmacopoeia for quantitative and purity analyses. Emodin is a type of anthraquinone, well known as the main active...
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Architectural Changes in the Medial Gastrocnemius on Sonography after Nerve Ablation in Healthy Adults

Park JE, Seong YJ, Kim ES, Park D, Lee Y, Park H, Rha DW

Architectural changes in healthy muscle after denervation have not yet been reported. This study aimed to investigate architectural changes in the medial head of the gastrocnemius muscle (GCM) after aesthetic...
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Protective effect of dietary oils containing omega-3 fatty acids against glucocorticoid-induced osteoporosis

Elbahnasawy AS, Valeeva ER, El-Sayed E, Stepanova

PURPOSE: Glucocorticoids (GCs) are implicated in secondary osteoporosis, and the resulting fractures cause significant morbidity. Polyunsaturated fatty acids (PUFAs) play a vital role in bone metabolism. However, few trials have...
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Prevalence of PALB2 Germline Mutations in Early-onset and Familial Breast/Ovarian Cancer Patients from Pakistan

Rashid MU, Khan FA, Muhammad N, Loya A, Hamann U

PURPOSE: Partner and localizer of BRCA2 (PALB2) is a breast cancer susceptibility gene that plays an important role in DNA repair. This is the first study assessing the prevalence of...
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A Multiplex Phytosterol Assay Utilizing Gas Chromatography-Mass Spectrometry for Diagnosis of Inherited Lipid Storage Disorders

Lee JH, Lee K, Jun SH, Song SH, Shin CH, Song J

No abstract available.
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Efficacy and local irritation evaluation of Eriobotrya japonica leaf ethanol extract

Seong NW, Oh WJ, Kim IS, Kim SJ, Seo JE, Park CE, Kim DY, Ko JW, Kim JC

BACKGROUND: Although Eriobotrya japonica leaves have been studied as a raw material for various cosmetic products, little is known about the anti-oxidant, anti-inflammatory, and anti-melanogenic activities of Eriobotrya japonica leaf...
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Neuraminidase Inhibitors from the Fruiting Body of Glaziella splendens

Kim JY, Woo EE, Ha LS, Ki DW, Lee IK, Yun BS

Neuraminidase (NA) cleaves the glycosidic bond linkages of sialic acids to release the mature virions from infected cells and has been an attractive therapeutic target for anti-influenza agents. In our...
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Chemical Constituents of Impatiens balsamina Stems and Their Biological Activities

Kim DH, Lee TH, Subedi L, Kim SY, Lee KR

The purification of the MeOH extract from Impatiens balsamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2 – 12)....
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