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Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus

Yeom JH, Lee IK, Ki DW, Lee MS, Seok SJ, Yun BS

During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance...
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Chemical Constituents of Gymnopilus spectabilis and Their Antioxidant Activity

Lee IK, Cho SM, Seok SJ, Yun BS

Gymnopilus spectabilis, a hallucinogenic mushroom belonging to the family Cortinariaceae, is found growing in dense clusters on stumps and logs of hardwoods and conifers. It contains the hallucinogenic alkaloid psilocybin...
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Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Action

Kim H, Choi HR, Kim DS, Park KC

Melanin is produced in melanocytes and stored in melanosomes. In spite of its beneficial sun-protective effect, abnormal accumulation of melanin results in esthetic problems. Hydroquinone, competing with tyrosine, is a...
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Arachidonic Acid Activates K+-Cl--cotransport in HepG2 Human Hepatoblastoma Cells

Lee YS

K+-Cl--cotransport (KCC) has been reported to have various cellular functions, including proliferation and apoptosis of human cancer cells. However, the signal transduction pathways that control the activity of KCC are...
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The Neuroprotective Effect of Maltol against Oxidative Stress on Rat Retinal Neuronal Cells

Song Y, Hong S, Iizuka Y, Kim CY, Seong GJ

PURPOSE: Maltol (3-hydroxy-2-methyl-4-pyrone), formed by the thermal degradation of starch, is found in coffee, caramelized foods, and Korean ginseng root. This study investigated whether maltol could rescue neuroretinal cells from...
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