- Comparison of In Vivo Pharmacokinetics and Pharmacodynamics of Vancomycin Products Available in Korea
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Kim HK, Choi SM, Kang G, Park KH, Lee DG, Park WB, Rhee SJ, Lee S, Jung SI, Jang HC
- KMID: 2471915
- Yonsei Med J.
- 2020 Apr;61(4):301-309.
- doi: 10.3349/ymj.2020.61.4.301
PURPOSE: Few studies have been investigated the in vivo efficacy of generic vancomycin products available outside of the United States. In this study, we aimed to compare the in vivo... -
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- Changes in the constituents and UV-photoprotective activity of Astragalus membranaceus caused by roasting
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Park JY, Lee JY, Kim HD, Jang GY, Seo KH
- KMID: 2461455
- J Nutr Health.
- 2019 Oct;52(5):413-421.
- doi: 10.4163/jnh.2019.52.5.413
PURPOSE: Astragalus membranaceus (AM) is an important traditional medicinal herb. Pharmacological research has indicated that AM has various physiological activities such as antioxidant, anti-inflammatory, immunoregulatory, anticancer, hypolipidemic, antihyperglycemic, and hepatoprotective... -
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- Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study
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Burr RL, Gu H, Cain K, Djukovic D, Zhang X, Han C, Callan N, Raftery D, Heitkemper M
- KMID: 2460485
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):551-562.
- doi: 10.5056/jnm19042
BACKGROUND/AIMS: Patients with irritable bowel syndrome (IBS) often report poor sleep quality. Whether poor sleep is associated with tryptophan (Trp) metabolites is unknown. We compared serum Trp metabolites in women... -
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- Melandrium firmum Extract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice
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Huang B, Kang BG, Lim SS, Zhang XH
- KMID: 2456226
- Ann Dermatol.
- 2019 Oct;31(5):502-510.
- doi: 10.5021/ad.2019.31.5.502
BACKGROUND: In our preliminary study, we screened for their potential to inhibit 5α-reductase, and Melandrium firmum (MF) extract showed the most potent activity as confirmed by high-performance liquid chromatography (HPLC). OBJECTIVE:... -
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- Biosynthetic Pathway of Indole-3-Acetic Acid in Basidiomycetous Yeast Rhodosporidiobolus fluvialis
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Bunsangiam S, Sakpuntoon V, Srisuk N, Ohashi T, Fujiyama K, Limtong S
- KMID: 2470140
- Mycobiology.
- 2019 Sep;47(3):292-300.
- doi: 10.1080/12298093.2019.1638672
IAA biosynthetic pathways in a basidiomycetous yeast, Rhodosporidiobolus fluvialis DMKU-CP293, were investigated. The yeast strain showed tryptophan (Trp)-dependent IAA biosynthesis when grown in tryptophan supplemented mineral salt medium. Gas chromatography–mass... -
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- Quantification of the Bioactive Components of the Rhizomes of Curcuma wenyujin and Assessment of Its Anti-inflammatory Effect in Benign Prostatic Hyperplasia-1 Cells
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Seo CS, Park E, Lee MY, Shin HK
- KMID: 2459966
- Nat Prod Sci.
- 2019 Sep;25(3):238-243.
- doi: 10.20307/nps.2019.25.3.238
In this study, the marker compounds of Curcumae Rhizoma (CR) were simultaneously quantified by high-performance liquid chromatography equipped with a photodiode array detector and the anti-inflammatory effects of CR extract... -
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- Assessment of the Purity of Emodin by Quantitative Nuclear Magnetic Resonance Spectroscopy and Mass Balance
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Park S, Choi YJ, Do GH, Seo EK, Hyun S, Lee D
- KMID: 2459963
- Nat Prod Sci.
- 2019 Sep;25(3):222-227.
- doi: 10.20307/nps.2019.25.3.222
Quantitative nuclear magnetic resonance (qNMR) is a well-established method adopted by international pharmacopoeia for quantitative and purity analyses. Emodin is a type of anthraquinone, well known as the main active... -
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- Prevalence of PALB2 Germline Mutations in Early-onset and Familial Breast/Ovarian Cancer Patients from Pakistan
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Rashid MU, Khan FA, Muhammad N, Loya A, Hamann U
- KMID: 2454291
- Cancer Res Treat.
- 2019 Jul;51(3):992-1000.
- doi: 10.4143/crt.2018.356
PURPOSE: Partner and localizer of BRCA2 (PALB2) is a breast cancer susceptibility gene that plays an important role in DNA repair. This is the first study assessing the prevalence of... -
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- Efficacy and local irritation evaluation of Eriobotrya japonica leaf ethanol extract
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Seong NW, Oh WJ, Kim IS, Kim SJ, Seo JE, Park CE, Kim DY, Ko JW, Kim JC
- KMID: 2456056
- Lab Anim Res.
- 2019 Jun;35(1):13-22.
- doi: 10.1186/s42826-019-0003-3
BACKGROUND: Although Eriobotrya japonica leaves have been studied as a raw material for various cosmetic products, little is known about the anti-oxidant, anti-inflammatory, and anti-melanogenic activities of Eriobotrya japonica leaf... -
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- Metabolomic Analysis Identifies Alterations of Amino Acid Metabolome Signatures in the Postmortem Brain of Alzheimer's Disease
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Kim YH, Shim HS, Kim KH, Lee J, Chung BC, Kowall NW, Ryu H, Lee J
- KMID: 2451073
- Exp Neurobiol.
- 2019 Jun;28(3):376-389.
- doi: 10.5607/en.2019.28.3.376
Despite significant advances in neuroscience research over the past several decades, the exact cause of AD has not yet fully understood. The metabolic hypothesis as well as the amyloid and... -
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- Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel
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San R, Yue W, Hasi S
- KMID: 2448701
- J Vet Sci.
- 2019 May;20(3):e12.
- doi: 10.4142/jvs.2019.20.e12
The effects of CYP1A enzyme on the pharmacokinetics of p-acetaminophen were studied in Bactrian camel. Twelve Bactrian camels were divided into 2 groups, then given a single dose of p-acetaminophen... -
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- Altered Sphingolipid Metabolism Is Associated With Asthma Phenotype in House Dust Mite-Allergic Patients
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Kowal K, Żebrowska E, Chabowski
- KMID: 2442045
- Allergy Asthma Immunol Res.
- 2019 May;11(3):330-342.
- doi: 10.4168/aair.2019.11.3.330
PURPOSE: Sphingolipids play an important role in cell growth, survival, inflammation and tissue remodeling. House dust mite (HDM) allergy is a major risk factor for asthma. The aim of the... -
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- Dried Blood Spot Multiplexed Steroid Profiling Using Liquid Chromatography Tandem Mass Spectrometry in Korean Neonates
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Choi R, Park HD, Oh HJ, Lee K, Song J, Lee SY
- KMID: 2431603
- Ann Lab Med.
- 2019 May;39(3):263-270.
- doi: 10.3343/alm.2019.39.3.263
BACKGROUND: Screening for congenital adrenal hyperplasia (CAH) using immunoassays for 17α-hydroxyprogesterone generates many false-positive results. We developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous quantification of... -
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- Microcytosis in children and adolescents with the sickle cell trait in Basra, Iraq
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Jaber RZ, Hassan MK, Al-Salait
- KMID: 2451054
- Blood Res.
- 2019 Mar;54(1):38-44.
- doi: 10.5045/br.2019.54.1.38
BACKGROUND: Microcytic anemia, the most common form of anemia in children and adolescents, is a heterogeneous group of diseases that is acquired or inherited. We assessed the frequency and causes... -
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- Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: a study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology
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Lee YK, Kim HJ, Lee K, Park SH, Song SH, Seong MW, Kim M, Han JY
- KMID: 2451051
- Blood Res.
- 2019 Mar;54(1):17-22.
- doi: 10.5045/br.2019.54.1.17
Genetic hemoglobin disorders are caused by mutations and/or deletions in the α-globin or β-globin genes. Thalassemia is caused by quantitative defects and hemoglobinopathies by structural defect of hemoglobin. The incidence... -
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- Rat Intestinal Acetic Acid and Butyric acid and Effects of Age, Sex, and High-fat Diet on the Intestinal Levels in Rats
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Choi SI, Kim N, Lee SM, Nam RH, Kang SR, Song CH, Park YT, Min H, Kim YR, Seok YJ
- KMID: 2447437
- J Cancer Prev.
- 2019 Mar;24(1):20-25.
- doi: 10.15430/JCP.2019.24.1.20
BACKGROUND: High-fat diet is known to be implicated in the pathogenesis of various metabolic disorders related to an inflammatory response. The aim of this study was to investigate the influence... -
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- Evaluation of the Suitability of Establishing Biological Exposure Indices of Styrene
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Choi AR, Im SG, Lee MY, Lee SH
- KMID: 2447330
- Saf Health Work.
- 2019 Mar;10(1):103-108.
- doi: 10.1016/j.shaw.2018.07.001
BACKGROUND: This study was designed to provide logical backgrounds for the revision of biological exposure indices (BEIs) for styrene exposure in Korea. In order to investigate the correlation between airborne... -
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- Effects of Titratable Acidity and Organic Acids on Enamel Erosion In Vitro
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Kim EJ, Jin BH
- KMID: 2446699
- J Dent Hyg Sci.
- 2019 Mar;19(1):1-8.
- doi: 10.17135/jdhs.2019.19.1.1
BACKGROUND: Erosion is a gradual process that occurs fairly quickly, and the full extent of the erosive effects of acidic beverages is not yet clear. The present study aimed to... -
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- Study on the Marker Steroids of New Zealand Deer (Cervus elaphus var. scoticus) Velvet Antler by UPLC-MS/MS and HPLC-PDA Methods - (II)
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Lee NK, Jang KH, Lee JT, Park HW, Han ST, In G
- KMID: 2443104
- Nat Prod Sci.
- 2019 Mar;25(1):49-58.
- doi: 10.20307/nps.2019.25.1.49
Eleven steroid hormones (SHs: androstene-3,17-dione, estrone, β-estradiol, α-estradiol, testosterone, dehydroepiandrosterone, 17á-hydroxyprogesterone, medroxyprogesterone, megestrol acetate, progesterone, and androsterone) were detected from New Zealand deer (Cervus elaphus var. scoticus) velvet antler (NZA,... -
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- Quantification of apixaban in human plasma using ultra performance liquid chromatography coupled with tandem mass spectrometry
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Jeong HC, Kim TE, Shin KH
- KMID: 2442244
- Transl Clin Pharmacol.
- 2019 Mar;27(1):33-41.
- doi: 10.12793/tcp.2019.27.1.33
Apixaban, an inhibitor of direct factor Xa, is used for the treatment of venous thromboembolic events or prevention of stroke. Unlike many other anticoagulant agents, it does not need periodic... -
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