Korean J Gynecol Oncol Colposc.
2003 Dec;14(4):290-299.
Oncogenic Pathways of Mitogen-activated Protein Kinases and Phosphatidylinositol 3-kinase in Epithelial Ovarian Cancer
- Affiliations
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- 1Department of Obstetrics and Gynaecology, BC Research Institute Children's and Women's Health, University of British Columbia, Vancouver, British Columbia, Canada.
- 2Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
- 3Department of Obstetrics and Gynaecology, College of Medicine, Dongguk University, Korea.
- 4Department of Obstetrics and Gynaecology, University of British Columbia, Canada.
- 5Department of Obstetrics and Gynaecology, College of Medicine, Hanyang University, Korea.
Abstract
- Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. The chemotherapeutic agents, growth factors and reproductive hormones have been demonstrated to activate MAPKs, suggesting that the MAPK signaling pathway plays an important role in the regulation of proliferation, apoptosis, survival and differentiation in response to these external stimuli in ovarian cancer. In addition to MAPKs as an oncogenic pathway, phosphatidylinositol 3-kinase (PI3K) plays a role in a various range of important cellular processes associated with malignant characterestics including cell growth, survival and migration, which is a member of lipid kinases subfamily that phosphorylates and dephosphorylates the 3-position of the inositol ring of phosphoinositides in a membrane. In this review, recent results of the MAPK and PI3K signaling cascades by external stimuli, and potential roles of these oncogenic pathways as an oncogenic pathway are summarized in epithelial ovarian cancer.
Keyword
MeSH Terms
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Apoptosis
Inositol
Intercellular Signaling Peptides and Proteins
Membranes
Mitogen-Activated Protein Kinases*
Ovarian Neoplasms*
Phosphatidylinositol 3-Kinase*
Phosphatidylinositols*
Phosphotransferases
Signal Transduction
Inositol
Intercellular Signaling Peptides and Proteins
Mitogen-Activated Protein Kinases
Phosphatidylinositol 3-Kinase
Phosphatidylinositols
Phosphotransferases
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