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Assessment of Developmental Toxicants using Human Embryonic Stem Cells

Hong EJ, Jeung EB

  • KMID: 2317839
  • Toxicol Res.
  • 2013 Dec;29(4):221-227.
Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid...
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Claudin-1, -2, -4, and -5: comparison of expression levels and distribution in equine tissues

Lee B, Kang HY, Lee DO, Ahn C, Jeung EB

Claudins, which are known as transmembrane proteins play an essential role in tight junctions (TJs) to form physical barriers and regulate paracellular transportation. To understand equine diseases, it is helpful...
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Calcium homeostasis in diabetes mellitus

Ahn C, Kang JH, Jeung EB

Diabetes mellitus (DM) is becoming a lifestyle-related pandemic disease. Diabetic patients frequently develop electrolyte disorders, especially diabetic ketoacidosis or nonketotic hyperglycemic hyperosmolar syndrome. Such patients show characteristic potassium, magnesium, phosphate,...
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Expression and regulation of Enpp2 in rat uterus during the estrous cycle

Ahn HJ, Yang H, An BS, Choi KC, Jeung EB

Ectonucleotide pyrophosphatase/phosphodiestrase 2 (Enpp2) isolated from the supernatant of human melanoma cells is a lysophospholipase D that transforms lysophosphatidylcholine into lysophospatidic acid. Although multiple analyses have investigated the function of...
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Uterine expression of tight junctions in the Canine uterus

Ahn C, Shin DH, Lee D, Kang HY, Jeung EB

Tight junctions (TJs) form continuous intercellular contacts in intercellular junctions. TJs involve integral proteins such as occludin (OCLN) and claudins (CLDNs) as well as peripheral proteins such as zona occludens-1...
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Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

Ayala-Cuellar AP, Kang JH, Jeung EB, Choi KC

Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to transdifferentiate into various lineages that develop from mesoderm. Their popular appeal as cell-based therapy was initially...
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Transcriptional and translational expression of calbindin-D9k in the duodenum, kidney and uterus of a female canine model

Sim JY, Jung EM, Yoo YM, Choi KC, Jeung EB

Calbindin-D9k (CaBP-9k) is a cytosolic calcium-binding protein expressed in tissues in the intestine, uterus, placenta, kidney, pituitary gland and bone. Its exact function is unknown, but it is considered to...
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Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells

Lee JH, Yoo YM, Lee B, Jeong S, Tran DN, Jeung EB

Background: Hypoxia causes oxidative stress and affects cardiovascular function and the programming of cardiovascular disease. Melatonin promotes antioxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione peroxidase, and catalase. Objectives: This...
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Conditional knockout of brca1/2 and p53 in mouse ovarian surface epithelium: Do they play a role in ovarian carcinogenesis?

Kim KY, Park DW, Jeung EB, Choi KC

Alterations of genes are known to be critical for the induction of tumorigenesis, but the mechanism of ovarian carcinogenesis is little understood and remains to be elucidated. In this study,...
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Oncogenic Pathways of Mitogen-activated Protein Kinases and Phosphatidylinositol 3-kinase in Epithelial Ovarian Cancer

Jeung EB, Park SH, Leung PC, Yang HS, Sim JC, Kim KT, Choi KC

  • KMID: 1980243
  • Korean J Gynecol Oncol Colposc.
  • 2003 Dec;14(4):290-299.
Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli, and mediate signal transduction from the cell surface...
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Multiple transcripts of anoctamin genes expressed in the mouse submandibular salivary gland

Han JH, Kim HM, Seo DG, Lee G, Jeung EB, Yu FH

PURPOSE: Salivary fluid formation is primarily driven by Ca2+-activated, apical efflux of chloride into the lumen of the salivary acinus. The anoctamin1 protein is an anion channel with properties resembling...
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