Ewha Med J.
1985 Sep;8(3):165-170. 10.12771/emj.1985.8.3.165.
Studies on the Hepatic Microsomal Mixed Function Oxidase System with Higenamine on the Rat
- Affiliations
-
- 1Department of Biochemistry, College of Medicine, Ewha Womans University, Korea.
- 2Department of Pharmacology, College of Medicine, Ewha Womans University, Korea.
- KMID: 1965658
- DOI: http://doi.org/10.12771/emj.1985.8.3.165
Abstract
- The effect of intraperitonelly administered higenamine on the cytochrome P -450, b5, P-nitroanisole-O-demethylase and lipid peroxidation in the rat hepatic microsomes were determined. The following results were obtained ; 1) The intraperitonelly administered higenamine increased contents of rat hepatic microsomal cytochrome P-450 and b5. 2) The principal role of cytochrome P-450 in mixed function oxidase reactions includes hydroxylation of various drugs, fatty acids, steroids, pesticides and carcinogens. The increased cytochrome P-450 induced by higenamine decreased on the both AAF of N-hydorxylation and Ring-hydroxylation. 3) Activity of P-nitroanisole-O-demethylase in hepatic microsomes with higenamine was decreased accorting to incresed dosage of higenamine. 4) The formation of lipid peroxides was increased according to increased dosage of higenamine.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Hepatic Microsomal Cytochrome P-450 Levels During Preimplatation in Rats
- Ethanol prevents from acetaminophen inducible hepatic necrosis by inhibiting its metabolic activation in mice
- An Experimental Study on Adrenergic Effect of Higenamine in Rabbit Cardiovascular System
- Effects of Exogenous Cholic Acid on Total Hepatic Cytochrome P-450 and b5 in the Bile Duct-ligated Rats
- The Effect of Vitamin A and alpha-Tocopherol on Hydroxylation of AAF in the Young Rat Liver Microsome
