Ewha Med J.  1985 Mar;8(1):11-19. 10.12771/emj.1985.8.1.11.

The Effect of Vitamin A and alpha-Tocopherol on Hydroxylation of AAF in the Young Rat Liver Microsome

• Sook HY
• Suk ST
• Eung SN

• KMID: 2170795
• DOI: http://doi.org/10.12771/emj.1985.8.1.11

Abstract

The principal role of cytochrome p-450 in mixed function oxidase reactions includes hydroxylation of vavious drugs, fatty acids, steroids, pesticides, and carcinogens. The effect of AAF, beta-NF with vitamin A, and alpha-tocopherol on hepatic micros-omal cytochrome p-450 content in young rats were investigated. The result is as follows; 1) The administrations of AAF, beta-NF increased contents of hepatic microsomal cytochrome p-450. 2) The increased amount of hepatic microsomal cytochrome p-450 include by AAF declined wien vitamin A, alpha-tocopherol and beta-NF were given. 3) AAF-ring-hydroxylation decreased in AAF group, but N-hydroxylation increased, compared to control group. 4) The administration of beta-NF or beta-NF and AAF increased both ring-hydrox-ylation and N-hydroxylation. 5) AAF-ring-bydroxylation increased when AAF was administrated with vitamin A, alpha-tocopherol, and beta-NF compared to AAF group.

MeSH Terms

alpha-Tocopherol*
Animals
Carcinogens
Cytochrome P-450 Enzyme System
Fatty Acids
Hydroxylation*
Liver*
Microsomes, Liver*
Oxidoreductases
Pesticides
Rats*
Steroids
Vitamin A*
Vitamins*
Carcinogens
Cytochrome P-450 Enzyme System
Fatty Acids
Oxidoreductases
Pesticides
Steroids
Vitamin A
Vitamins
alpha-Tocopherol