- The Effects of Phenobarbital or Cholic Acid on Hepatic Microsomal Cytochrome P450 and Hydroxylation of 2-AAF in Cholestatic Rats
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Kim BH, Hong YS, Sung NE
- KMID: 1969538
- Ewha Med J.
- 1981 Sep;4(3):83-89.
- doi: 10.12771/emj.1981.4.3.83
In cholestatic rats, effects of phenobarbital or cholic acid on hepatic microsomal cytochrome p-450 and b5 were investigated. The total contents of both cytochrome p-450 and cytochrome b5 were decreased... -
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- The Effect of Vitamin A and alpha-Tocopherol on Hydroxylation of AAF in the Young Rat Liver Microsome
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Sook HY, Suk ST, Eung SN
- KMID: 2170795
- Ewha Med J.
- 1985 Mar;8(1):11-19.
- doi: 10.12771/emj.1985.8.1.11
The principal role of cytochrome p-450 in mixed function oxidase reactions includes hydroxylation of vavious drugs, fatty acids, steroids, pesticides, and carcinogens. The effect of AAF, beta-NF with vitamin A,... -
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- Inhibition of Carcinogenic Effects of N-Hydroxy-e-acetylaminofluorene by Vitamin Antioxidants
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Sung NE, Hong YS
- KMID: 1969219
- Ewha Med J.
- 1982 Sep;5(3):99-107.
- doi: 10.12771/emj.1982.5.3.99
The principal role of cytochrome P-450 in many other mixed function oxidase reactions including hydroxylations or oxidative dealkylations of various drugs, fatty acids, steroids, pesticides, and carcinogens. In order to... -
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- Effect of Thiamine Deficiency on Drug Hydroxylation and Level of Cytochrome P-450 in the Rats
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Kim BH, Hong YS, Sung NE
- KMID: 1969656
- Ewha Med J.
- 1979 Dec;2(4):195-199.
- doi: 10.12771/emj.1979.2.4.195
Our studies are concerned with cytochrome P-450 content and 2-acetylaminofluorene N-and ring-hydroxylation by thiamine deficient rat liver microsomes. Incubation medium contained 100mM HEPES buffer pH 7.8, 2mM NADPH, 100mM KF,... -
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- Effects of Chronic Alcohol Feeding on the Lipid Contents in the Rat Liver and the Hepatic Microsomal 2-Acetylaminofluorene(1-AAF) Hydroxylation in Vitro
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Choi KJ
- KMID: 1967728
- Ewha Med J.
- 1983 Mar;6(1):35-46.
- doi: 10.12771/emj.1983.6.1.35
It is now well established that ethanol excerts different effect on hepatic cellular metabolism, depending mainly on the duration of its intake. And induction of quantitative and qualitative alterations in... -
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- The Effects of Vitamin B Complexes on AAF Hydroxylation by Rat Liver Microsomal Cytochrome P-450
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Hong YS, Kim BH, Sung NE
- KMID: 1969574
- Ewha Med J.
- 1980 Sep;3(3):113-118.
- doi: 10.12771/emj.1980.3.3.113
The effects of vitamin B complexes on both ring and N-hydroxylation of 2-ace-tylaminofluorene by rat hepatic microsomal fraction were studied. In the presence of thiamine-Hcl during incubation, the total hydroxy-AAF was... -
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- Effects of Chronic Ethanol Administration and Cold Exposure on Rabbit Adrenocorticoid 11beta-Hydroxylase and 18-Hydroxylase Activities
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Lee DY, Sung NE
- KMID: 1967724
- Ewha Med J.
- 1983 Mar;6(1):3-15.
- doi: 10.12771/emj.1983.6.1.3
Rabbit adrenocrtical mitochondria contains cytochrome P-450 dependent hydrox-ylase system, capable of catalyzing the hydroxylation as well as other modifications of variety of lipids and foreign compounds, including drugs, pesticides, carcino-gens.... -
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- Effect of Various Anesthetics on the Hepatic Microsomal Cytochrome System and the Lipid Contents of Albino Rats
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Lee YJ, Sung NE
- KMID: 1969223
- Ewha Med J.
- 1982 Sep;5(3):147-163.
- doi: 10.12771/emj.1982.5.3.147
The cytochrome enzyme system of hepatic microsomes is important because of its versatility, being capable of catalysing the hydroxylation as well as other modifications of variety of lipids and foreign... -
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- Studies on the Hepatic Microsomal Mixed Function Oxidase System with Higenamine on the Rat
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Hong YS, Pae YS, Sung NE
- KMID: 1965658
- Ewha Med J.
- 1985 Sep;8(3):165-170.
- doi: 10.12771/emj.1985.8.3.165
The effect of intraperitonelly administered higenamine on the cytochrome P -450, b5, P-nitroanisole-O-demethylase and lipid peroxidation in the rat hepatic microsomes were determined. The following results were obtained ; 1)... -
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- Evaluation of Luminescent P450 Analysis for Directed Evolution of Human CYP4A11
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Choi S, Han S, Lee H, Chun YJ, Kim D
- KMID: 2170668
- Biomol Ther.
- 2013 Nov;21(6):487-492.
Cytochrome P450 4A11 (CYP4A11) is a fatty acid hydroxylase enzyme expressed in human liver. It catalyzes not only the hydroxylation of saturated and unsaturated fatty acids, but the conversion of... -
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- Studies on the protein biosynthesis in isolated periodontal ligament
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Chung HI
- KMID: 2271422
- Korean J Orthod.
- 1979 Dec;9(1):9-14.
The purpose of this study was to pursue the biosynthesis of proteins of human and bovine periodontal ligaments in vitro system. The excised periodontal ligaments from human and bovine were... -
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- 3 Cases of Congenital Adrenal Hyperplasia
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Kim KS, Kim DS, Kim SK, Kim KH, Kim DH, Yun DJ
- KMID: 1668024
- J Korean Pediatr Soc.
- 1980 Aug;23(8):662-669.
We present 3 cases of congenital hyperplasia. Case lis a 5 year and 9 month old who is suffered from excessive salt craving and symptoms of precocious puberty. Case llis... -
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- The Effects of Ascorbic Acids on the Proliferation of the Human & Rabbit Tenon's Fibroblasts
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Lee SY, Ahn JH, Lew HM
- KMID: 2205635
- J Korean Ophthalmol Soc.
- 1999 Nov;40(11):3017-3024.
Although ascorbic acids have been known to play a role in the hydroxylation of procollagen in collagen synthesis, it can also inhibit the proliferation of fibroblasts at high concentrations. The... -
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- HIF-1alpha: a Valid Therapeutic Target for Tumor Therapy
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Hong SS, Lee H, Kim KW
- KMID: 2166124
- Cancer Res Treat.
- 2004 Dec;36(6):343-353.
Hypoxia plays a major role in the induction of angiogenesis during tumor development. One mechanism by which tumor cells respond to a reduced oxygen level is via the activation of... -
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- Cytochrome P-450 Dependent Hydroxylation of Chemical Carcinogens
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Hong YS
- KMID: 1969639
- Ewha Med J.
- 1979 Jun;2(2):75-82.
- doi: 10.12771/emj.1979.2.2.75
A large number of chemicals have the ability to induce cancer in a variety of tissues of various hosts, including man. Despite current interest in the viral etiology of a... -
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- Formation of 8-hydroxydeoxyguanine moiety in human bladder cellular DNA by bladder carcinogens
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Lee SW, Kim SW, Chung MH
- KMID: 2036794
- Korean J Urol.
- 1993 Feb;34(1):16-25.
The 8-hydroxydeoxyguanosine (8-OH-dG), DNA adduct produced by oxygen radical-induced hydroxylation of C-8 position of guanine residue is accepted as to cause mutation and associate with carcinogenesis, and there are many... -
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- A Study on the Debrisoquine Metabolism in a Group, of Korean Population
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Lee MH, Moon HY, Son MH, Sohn SJ, Choi JS
- KMID: 2282704
- Korean J Prev Med.
- 1994 Sep;27(3):569-580.
The genetically determined ability to metabolize debrisoquine(DBR) is related to risk of lung cancer and DBR hydroxylation exhibits wide inter-individual variation. In this study, 100 korean adults were tested for... -
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- Induction of Hepatic Microsomal Cytochrome P450 by N,N-dimethylformamide in Sprague-Dawley Rats
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Koh SB, Cha BS, Kim KJ, Kang SK, Joung HS
- KMID: 2282984
- Korean J Prev Med.
- 1999 Feb;32(1):88-94.
OBJECTIVES: In order to gain a better understanding of the mechanism of DMF toxicity, recent studies have focused on hepatic drug metabolizing enzymes. In this study, we investigated the effects... -
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- Vitamin D dependent rickets type I
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Kim CJ
- KMID: 2073621
- Korean J Pediatr.
- 2011 Feb;54(2):51-54.
- doi: 10.3345/kjp.2011.54.2.51
Vitamin D is present in two forms, ergocalciferol (vitamin D2) produced by plants and cholecalciferol (vitamin D3) produced by animal tissues or by the action of ultraviolet light on 7-dehydrocholesterol... -
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