J Korean Assoc Maxillofac Plast Reconstr Surg.  1997 Feb;19(1):109-114.

Malignant Hyperthermia: A Case Report

• Chang HW
• Park KS
• Kim CW
• Nam DS
• Park HS
• Park NB
• Kim JB

Abstract

Malignant hyperthermia is a hypermetabolic, fatal syndrome triggered by anesthetic drugs that occurs frequently in genetically susceptible persons. It is characterized by tachycardia, rapidly increasing temperature, skeletal muscle rigidity, respiratory and metabolic acidosis, cyanosis etc. It has been noted that the majority of cases of malignant hyperthermia are fatal unless early diagnosis and treatment are performed Thus, the accurate prediction of preanesthetic susceptibility and early diagnosis of malignant hyperthermia is necessary to appropriate treatment. Dantrolene sodium has been shown to be effective in the prevention and treatment of malignant hyperthermia. We experienced a case of malignant hyperthermia, which is presented of a 32-year-old healthy male patient in whom a orthognatic surgery was performed under O2-N2O-enfl-rane anesthesia with induction by pentobarbital and succinylcholine. We discuss this case with reviewing the history, incidence, etiology, pathophysiology, clinical signs & biochemical changes, prevention & treatment.

Keyword

Malignant hyperthermia; Fatal syndrome

MeSH Terms

Acidosis
Adult
Anesthesia
Anesthetics
Cyanosis
Dantrolene
Early Diagnosis
Humans
Incidence
Male
Malignant Hyperthermia*
Muscle, Skeletal
Pentobarbital
Succinylcholine
Tachycardia
Anesthetics
Dantrolene
Pentobarbital
Succinylcholine