Korean J Crit Care Med.  2009 Dec;24(3):168-171. 10.4266/kjccm.2009.24.3.168.

Delayed Onset of Malignant Hyperthermia: A Case Report

• Lim JW
• Yeo SK
• Yang SH
• Hwang IS
• Lee JS

• KMID: 2228326
• DOI: http://doi.org/10.4266/kjccm.2009.24.3.168

Abstract

Malignant hyperthermia is a potentially fatal genetic and metabolic myopathy that presents with high fever, and muscle rigidity, and it often occurs after administering anesthetic medication. Most cases of malignant hyperthermia occur during anesthesia or surgery, but delayed malignant hyperthermia is very rare, and if it is detected late, it has a high mortality rate. A 39-year-old male with an acute subdural hematoma underwent decompressive craniectomy without any intraoperative medical problems, but a high fever above 40degrees C occurred after 8 hours and he was dead in spite of aggressive management after 48 hours postoperatively. We present here a case of delayed malignant hyperthermia along with a review of the related literature.

Keyword

delayed malignant hyperthermia; ryanodine receptor; sevoflurane

MeSH Terms

Adult
Anesthesia
Decompressive Craniectomy
Fever
Hematoma, Subdural, Acute
Humans
Male
Malignant Hyperthermia
Methyl Ethers
Muscle Rigidity
Muscular Diseases
Ryanodine Receptor Calcium Release Channel
Methyl Ethers
Ryanodine Receptor Calcium Release Channel