Korean J Anat.
2006 Apr;39(2):111-118.
Activation of Nuclear Factor-kappaB in the Atherosclerotic Human Coronary Artery
- Affiliations
-
- 1Department of Anantomy, College of Medicine, Kangwon National University, Korea. camackim@kangwon.ac.kr
- 2Department of Anesthesiology, Eulji School of Medicine, Korea.
- 3Department of Anatomy, Gachon Medical School, Korea.
- 4Department of Forensic Medicine, National Institute of Scientific Investigation, Korea.
Abstract
- Paraffin sections of atherosclerotic vessels were classified into initial lesion, preatheroma and complicated severe lesion by classification method from American Heart Association. Activation of NF-kappaB was hardly detectable in the initial atherosclerotic lesion. In the preatheroma, activated NF-kappaB was enhanced in the neointimal smooth muscle cells and macrophages in the lipid core. In contrast, activated NF-kappaB increased markedly in the neointimal and medial smooth muscle cells in the severe atherosclerotic vessel wall. However, in the severe lesion, NF-kappaB activation was diminished in the macrophages of lipid core. Our findings show that NF-kappaB was activated in the smooth muscle cells with the progression of atherosclerosis in the human coronary artery.
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