Korean J Urol.
1995 Feb;36(2):121-127.
Interleukin-4 Receptor Expression on Human Renal Cell Carcinoma Cell Lines by a Reverse Transcription-Polymerase Chain Reaction
- Affiliations
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- 1Department of Urology, College of Medicine, Korea University, Seoul, Korea.
- 2Department of Biochemistry, College of Medicine, Korea University, Seoul, Korea.
Abstract
- Recently interleukin-4 (IL-4) has been suggested to be a promising therapeutic agent for the malignant tumors of both murine and human origin. The effect of IL-4 is mediated by IL-4 receptor (IL-4R), which has been shown to be expressed in many normal and tumor cell lines. We herein tested two cell lines of human renal cell carcinoma (RCC), Caki-1 and CURC-II, for the expression of IL-1R gene. On the reverse transcription-polymerase chain reaction study, both cell lines expressed IL-4R mRNA. The present study suggests that it would be worthwhile to investigate the anti-tumor effect of IL-4 on Caki-l and CIJRC-II, which may help to develop new therapeutic strategies for RCC using IL-4.
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