Anat Cell Biol.  2014 Sep;47(3):149-156. 10.5115/acb.2014.47.3.149.

Neuroprotection of antioxidant enzymes against transient global cerebral ischemia in gerbils

• Lee JC
• Won MH

• KMID: 1882589
• DOI: http://doi.org/10.5115/acb.2014.47.3.149

Abstract

Experimentally transient global cerebral ischemia using animal models have been thoroughly studied and numerous reports suggest the involvement of oxidative stress in the pathogenesis of neuronal death in ischemic lesions. In animal models, during the reperfusion period after ischemia, increased oxygen supply results in the overproduction of reactive oxygen species (ROS), which are involved in the process of cell death. ROS, such as superoxide anions, hydroxyl free radicals, hydrogen peroxide and nitric oxide are produced as a consequence of metabolic reactions and central nervous system activity. These reactive species are directly involved in the oxidative damage of cellular macromolecules such as nucleic acids, lipids and proteins in ischemic tissues, which can lead to cell death. Antioxidant enzymes are believed to be among the major mechanisms by which cells counteract the deleterious effect of ROS after cerebral ischemia. Consequently, antioxidant strategies have been long suggested as a therapy for experimental ischemic stroke; however, clinical trials have not yet been able to promote the translation of this concept into patient treatment regimens. This article focuses on the contribution of oxidative stress or antioxidants to the post-ischemic neuronal death following transient global cerebral ischemia by using a gerbil model.

Keyword

Mongolian gerbil; Global cerebral ischemia; Neuronal death; Reactive oxygen species; Antioxidants

MeSH Terms

Antioxidants
Brain Ischemia*
Cell Death
Central Nervous System
Free Radicals
Gerbillinae*
Humans
Hydrogen Peroxide
Ischemia
Models, Animal
Neurons
Nitric Oxide
Nucleic Acids
Oxidative Stress
Oxygen
Reactive Oxygen Species
Reperfusion
Stroke
Superoxides
Antioxidants
Free Radicals
Hydrogen Peroxide
Nitric Oxide
Nucleic Acids
Oxygen
Reactive Oxygen Species
Superoxides

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