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Comparison of age‐dependent alterations in thioredoxin 2 and thioredoxin reductase 2 expressions in hippocampi between mice and rats

Yoo YH, Kim DW, Chen BH, Sim H, Kim B, Lee JC, Ahn JH, Park Y, Cho JH, Kang IJ, Won MH, Lee TK

Background Aging is one of major causes triggering neurophysiological changes in many brain substructures, including the hippocampus, which has a major role in learning and memory. Thioredoxin (Trx) is a class...
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Analysis of Body Fat Mass Index for Korean Adults

Kwon MH, Han B, Cho SJ, Cho JH

Background: Body mass index (BMI), a standard guideline used by the World Health Organization to diagnose obesity, has limited ability to differentiate between lean body mass and fat body mass....
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Relationship between Mental Health Status of Teenagers and Academic Achievement: Korea Youth Risk Behavior Web-Based Survey, 2018

Cho JH, Cho SJ, Kwon MH

Background: The developmental stage of adolescence contains many tasks assisting in the ability to grow into a healthy adult; however, numerous studies have reported that a majority of teenagers today...
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Gene expression profiling of mouse cavernous endothelial cells for diagnostic targets in diabetes-induced erectile dysfunction

Yin GN, Ock J, Choi MJ, Limanjaya A, Ghatak K, Song KM, Kwon MH, Suh JK, Ryu JK

Purpose: To investigate potential target genes associated with the diabetic condition in mouse cavernous endothelial cells (MCECs) for the treatment of diabetes-induced erectile dysfunction (ED). Materials and Methods: Mouse cavernous tissue...
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Three-Dimensional Reconstruction of Neurovascular Network in Whole Mount Preparations and ThickCut Transverse Sections of Mouse Urinary Bladder

Nguyen NM, Song KM, Choi MJ, Ghatak K, Limanjaya A, Kwon MH, Chung DY, Ock J, Yin GN, Park CS, Suh JK, Ryu JK

Purpose: Proper functional and structural integrity of nervous and vascular system in urinary bladder plays an important role in normal bladder function and the disruption of these structures is known...
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High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils

Seo WJ, Ahn JH, Lee TK, Kim B, Lee JC, Park JH, Yoo YH, Shin MC, Cho JH, Won MH, Park Y

Obesity has been known as an independent risk factor for stroke. Effects of high-fat diet (HFD)-induced obesity on neuronal damage in the somatosensory cortex of animal models of cerebral ischemia...
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Brain Factor-7® improves learning and memory deficits and attenuates ischemic brain damage by reduction of ROS generation in stroke in vivo and in vitro

Noh Y, Lee JW, Hong J, Kim SS, Ahn JH, Lee TK, Kim B, Won MH

Brain Factor-7® (BF-7), silk fibroin peptide, is known to be effective in improvement of memory and learning ability. In this study, the effects of BF-7 (10 mg/kg, p.o., pre-treatment for 7 days...
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Associations between Living Alone and Smoking and Alcohol Consumption in Korean Adults

Lee SW, Han B, Cho SJ, Jung SJ, Huh Y, Kim J, Eum DH, Kim T, Min SH, Lee W, Cho J, Kwon MH, Nam GE

Background: Recently, single-person households have increased in Korea and this trend may have potential public health implications and affect various health behaviors. This study investigated the associations between living alone...
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Vactosertib, a Novel, Orally Bioavailable Activin Receptor-Like Kinase 5 Inhibitor, Promotes Regression of Fibrotic Plaques in a Rat Model of Peyronie’s Disease

Song KM, Chung DY, Choi MJ, Ghatak K, Nhat Minh N, Limanjaya A, Kwon MH, Ock J, Yin GN, Kim DK, Ryu JK, Suh JK

Purpose: To examine the therapeutic effect of Vactosertib, a small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor (activin receptor-like kinase-5, ALK5), in an experimental model of Peyronie’s...
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A Simple and Nonenzymatic Method to Isolate Human Corpus Cavernosum Endothelial Cells and Pericytes for the Study of Erectile Dysfunction

Yin GN, Ock J, Choi MJ, Song KM, Ghatak K, Minh NN, Kwon MH, Seong DH, Jin HR, Ryu JK, Suh JK

PURPOSE: To establish a simple and nonenzymatic technique to isolate endothelial cells (ECs) and pericytes from human corpus cavernosum tissue and to evaluate the angiogenic ability of the human cavernous...
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Arg-Leu-Tyr-Glu Suppresses Retinal Endothelial Permeability and Choroidal Neovascularization by Inhibiting the VEGF Receptor 2 Signaling Pathway

Park W, Baek YY, Kim J, Jo DH, Choi S, Kim JH, Kim T, Kim S, Park M, Kim JY, Won MH, Ha KS, Kim JH, Kwon YG, Kim YM

Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the...
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RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia

Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH

Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the...
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A Prediction Model for Physical Activity Adherence for Secondary Prevention among Patients with Coronary Artery Disease

Won MH, Kim O

PURPOSE: The purpose of this study was to construct and test a predictive model for physical activity adherence for secondary prevention among patients with coronary artery disease. METHODS: Two hundred and...
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Mediating Effect of Physical Activity in the Relationship between Depressive Symptoms and Health-related Quality of Life in Patients with Coronary Artery Disease: The 2016 Nationwide Community Health Survey in Korea

Won MH

PURPOSE: This study aimed to examine the mediating role of physical activity in the relationship between depressive symptoms and health-related quality of life in patients with coronary artery disease. METHODS: A...
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Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus

Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH

P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult...
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Preliminary Study of the Antioxidant Effects of Oenanthe javanica Extract on the Skin of Aged Mice

Her Y, Shin BN, Lee HS, Min JH, Won MH, Lee YL

  • KMID: 2433652
  • Korean J Dermatol.
  • 2019 Jan;57(1):53-56.
No abstract available.
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The relationship between low survival and acute increase of tumor necrosis factor α expression in the lung in a rat model of asphyxial cardiac arrest

Park Y, Tae HJ, Cho JH, Kim IS, Ohk TG, Park CW, Moon JB, Shin MC, Lee TK, Lee JC, Park JH, Ahn JH, Kang SH, Won MH, Cho JH

Cardiac arrest (CA) is sudden loss of heart function and abrupt stop in effective blood flow to the body. The patients who initially achieve return of spontaneous circulation (RoSC) after...
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Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-β1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque

Kang DH, Yin GN, Choi MJ, Song KM, Ghatak K, Minh NN, Kwon MH, Seong DH, Ryu JK, Suh JK

PURPOSE: Epigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to...
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Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation

Koo BH, Yi BG, Wang WK, Ko IY, Hoe KL, Kwon YG, Won MH, Kim YM, Lim HK, Ryoo S

PURPOSE: Vascular smooth muscle cell (VSMC) proliferation induced by native low-density lipoprotein (nLDL) stimulation is dependent on superoxide production from activated NADPH oxidase. The present study aimed to investigate whether...
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Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs

Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S

Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that...
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