The Changes of HPV Titration after Retinoic Acid Treatment in Korean Patients with Dysplasia of the Uterine Cervix

Kong, K H; Jung, S A; Kim, J B; Ahn, S B; Lee, H G; An, W S; Namkoong, S E; Kim, S J

Abstract

Retinoids have been recognized as a family of molecules capable of profound impact on many biologic functons, also known to possess antiproliferative, differentiative, and immunomodulatory properties. However, only recently have laboratory and precoinical and clinical oncology reseatch made this knowledge immediately relevant to the problem of malignancy. Cervical cancer is thr second most common malignancy in women worldwide and remains a significant health problem in women. While the natural history is well known, little is known of the pathobiology of cervical carcinogenesis, prevention of cervical cancer and its precursors are impprtant objectives. To assess the effect of 13-cis-retinoic acid (13-CRA) in the rteatment of 13 chronic cervicitis and 52 cervical intraepithelial neoplasia, we examined lower and high risk Human Papilloma Virus (HPV) titration (using Hybrid Capture system) and colposcopic and cervicographic examination before and after rteatment with 13-CRA 1mg/kg for 4 to 12 weeks. The following results were obtainted : 1. The age distributon of patients was between 23 years and 64 year, average 36.6 years old. 2. Histology revealed the chronic cervicitis 13 cases, mild dysplasia 18 cases, moderate dysplasia 18 cases and severe dysplasia 16 cases, total 65 cases. 3. Among these groups the expression rates of high risk Human Papilloma Virus (HPV 16, 18) were 9 of 13 cases (69%) in chronic cervictis, 7 of 18 cases (39%) in mild dysplasia, 9 of 18 cases (50%) in moderate dysplasia and 12 of 16 cases (75%) in severe dysplasia, overall expression rate was 37 of 65 cases (57%) 4. After treatment, decreasing changes of HPV titration (high risk)vy hybrid capture system were 6 of 9 cases (66%) of chronic cervictis, 3 of 7 cases (43%) of mild dysplasia, 7 or 9 cases (77%) of moderate dysplasia, 8 of 12 cases (75%) of severe dysplasia,overall decreasing rate was 25 of 41 cases (61%).