Korean J Obstet Gynecol.  2000 Jul;43(7):1194-1199.

Detection of Human Papilloma Virus Type 16 and 18 in Adenocarcinoma in situ of the Uterine Cervix

• Ha YO
• Choi EJ
• Lee TS

Abstract

OBJECTIVE
The purpose of this study was to assess the role of HPV 16 and 18 in adenocarcinoma in situ(ACIS) of the uterine cervix.
METHODS
Seventeen cases of primary cervical adenocarcinoma in situ were analyzed for HPV DNA by polymerase chain reaction. HPV 16 and 18 DNA extracted from formalin-fixed, paraffin-embedded histologic tissue sections by polymerase chain reaction.
RESULTS
35.3% and 23.5% of ACIS were positive for HPV 16 and HPV 18 DNA, respectively. From the normal tissue, 11.8% were positive for HPV 16. Human papillomavirus positive patients were younger than negative patients but statistically insignificant(mean age 42.1 vs 51.7 years).
CONCLUSIONS
These results show that HPV type 16 and 18 were closely related to etiology of the ACIS of the uterine cervix.

Keyword

Adenocarcinoma in situ; Age; Human papillomavirus

MeSH Terms

Adenocarcinoma*
Cervix Uteri*
DNA
Female
Human papillomavirus 16
Human papillomavirus 18
Humans*
Papilloma*
Polymerase Chain Reaction
DNA