J Korean Neurol Assoc.
1999 May;17(3):359-364.
D3 and D5 Dopamine Receptor mRNA Expression in Peripheral Blood Mononuclear Cells from Patients with Parkinson's Disease
- Affiliations
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- 1Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
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BACKGROUND: Among 5 subfamilies of dopamine receptors (DAR), D3 and D5 DAR are expressed on peripheral blood mononuclear cells (PBMC). Recently, those DARs have been reported to change in Parkinson's disease (PD).
METHODS
We measured the DAR mRNA expression in PBMC from 15 PD patients who had never taken antiparkinson medication, and 16 age-matched healthy people by reverse transcription and quantitative competitive polymerase chain reaction. The beta-actin mRNA expression was also measured to evaluate the relative expression of DAR mRNA.
RESULTS
The D3 and D5 DAR mRNA expression was not different between patients and controls. In patients, no significant cor-relation was found between DAR mRNA expression in PBMC and clinical variables such as severity and duration of symptoms, and patients' age.
CONCLUSIONS
We confirmed the presence of D3 and D5 DAR in PBMC. However, their mRNA expressions were not influenced by the disease process of PD.
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