Gut Liver.  2013 Sep;7(5):560-568.

The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach

Affiliations
  • 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. nayoungkim49@empas.com
  • 2Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • 3Life Science R&D Center, SK Chemicals, Suwon, Korea.

Abstract

BACKGROUND/AIMS
Cochinchina momordica seed extract (SK-MS10) has a gastric protective effect. We aimed to assess the effect of SK-MS10 on gastric acid secretion with morphologic changes in the aged rat.
METHODS
Acid secretions were evaluated in the male F344 rats of four different ages (6-, 31-, 74-week, and 2-year). The 31-week-old rats were divided to three groups and continuously administered chow containing vehicle, SK-MS10 and lansoprazole, respectively. At the age of 74 weeks and 2 years, basal and stimulated acid was measured and the expression of mRNA and protein of H(+)-K(+)-ATPase were determined. The area of connective tissue of lamina propria was measured.
RESULTS
Basal and stimulated gastric acid significantly decreased and connective tissue of lamina propria increased with age. The expression of mRNA and protein of H(+)-K(+)-ATPase significantly decreased with age. However, 74-week-old rats in the SK-MS10 group had higher stimulated gastric acid secretion than those in the vehicle and lansoprazole groups. In 2-year-old rats of SK-MS10 group, there was no increase of connective tissue.
CONCLUSIONS
As SK-MS10 kept the capacity of acid secretion as well as connective tissue area to comparable to young rats, it might valuable to perform further research regarding mechanism of SK-MS10 as an antiaging agent in the stomach.

Keyword

Gastric acid; Hydrogen-potassium-activated ATPase; Cochinchina momordica seed; Aging; Connective tissue

MeSH Terms

2-Pyridinylmethylsulfinylbenzimidazoles
Aged
Aging
Animals
Connective Tissue
Gastric Acid
Humans
Male
Momordica
Mucous Membrane
Preschool Child
Rats
Rats, Inbred F344
RNA, Messenger
Seeds
Stomach
2-Pyridinylmethylsulfinylbenzimidazoles
RNA, Messenger
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