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Increasing Prevalence and Mortality of Asthma With Age in Korea, 2002–2015: A Nationwide, Population-Based Study

Lee E, Kim A, Ye YM, Choi SE, Park HS

PURPOSE: The prevalence of asthma is increasing globally as the world population increases; however, and the prevalence and mortality of asthma have not been extensively investigated. Also, the effects of...
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Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases

Kang MJ

Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our understanding of the molecular mechanisms underlying...
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Relationship between Hypogonadal Symptoms, Sexual Dysfunction and Chronic Prostatitis in Middle-Aged Men by Self-Reported Questionnaires, even without Biochemical Testosterone Deficiency

Lee MH, Seo DH, Lee CW, Choi JH, Jeh SU, Lee SW, Choi SM, Hwa JS, Hyun JS, Chung KH, Kam SC

PURPOSE: To investigate the association of erectile dysfunction (ED), premature ejaculation (PE), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men with late-onset hypogonadism (LOH). MATERIALS AND METHODS: We reviewed the...
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Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?

Walther A, Seuffert J

Although demographic statistics show that populations around the world are rapidly ageing, this rising life expectancy is accompanied by an increase in the number of people living with age-related chronic...
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Timing of Hip-fracture Surgery in Elderly Patients: Literature Review and Recommendations

Seong YJ, Shin WC, Moon NH, Suh KT

The incidence of hip fractures is rapidly increasing with an aging population and is now one of the most important health concerns worldwide due to a high mortality rate. The...
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Connecting the dots between SHP2 and glutamate receptors

Ryu HH, Kim SY, Lee YS

SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological...
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Opioids and Antidepressants for Pain Control in Musculoskeletal Disease

Park SJ, Kim WS, Jang T

The progression of aging and the increase in musculoskeletal diseases have led to an increase in invasive treatment methods, including various surgical methods, but conservative treatment should be attempted before...
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Current trends in minimally invasive surgery for benign prostatic hyperplasia

Choo MS, Son H

The prevalence of benign prostatic hyperplasia (BPH) is rising with Korea becoming an aging society. As patients age, their comorbidities and the risks associated with anesthesia increase. Recently, there has...
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Macular Pigment Optical Density in the Korean Population: a Cross Sectional Study

Hong IH, Jung WH, Lee JH, Chang IB

BACKGROUND: To evaluate the macular pigment optical density (MPOD) with age in the Korean population using the Macular Pigment Screener II (MPSII®). METHODS: One hundred and twenty-six eyes were retrospectively reviewed....
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The Effects of Meal Timing and Frequency, Caloric Restriction, and Fasting on Cardiovascular Health: an Overview

Maugeri A, Vinciguerra M

Cardiovascular disease (CVD), which is the leading cause of death worldwide, is strongly affected by diet. Diet can affect CVD directly by modulating the composition of vascular plaques, and indirectly...
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Cellular Senescence in Arterial Diseases

Shimizu I, Minamino T

Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the...
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Age-specific variations in hematological and biochemical parameters in middle- and large-sized of dogs

Lee SH, Kim JW, Lee BC, Oh HJ

Aging triggers cellular and molecular alterations, including genomic instability and organ dysfunction, which increases the risk of disease in mammals. Recently, due to the markedly growing number of aging dogs...
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Differential Activation of Macrophages Based on Their Environment in Advanced Age

Lee DY, Lim JS, Cho KA

The macrophage displays functional and phenotypic diversity, which appears, in no small part, to stem from the ability of macrophages to adapt functionally to changes in their tissue microenvironment. Here,...
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Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway

Kim SG, Sung JY, Kim JR, Choi HC

Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance...
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Testosterone Replacement Therapy for Patients with Hypogonadism after High Dose-Rate Brachytherapy for High-Risk Prostate Cancer: A Report of Six Cases and Literature Review

Kadomoto S, Shigehara , Iwamoto H, Yaegashi H, Izumi K, Kadono Y, Mizokami A

We had six cases of patients who were treated with long-term testosterone replacement therapy (TRT) after high dose-rate (HDR) brachytherapy and androgen deprivation therapy for high-risk prostate cancer. All patients...
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Upcoming Aging Society and Men's Health: Focus on Clinical Implications of Exercise and Lifestyle Modification

Park B, Lee YJ

Recent epidemiological research has indicated that men have increased health risks due to biological and social factors. Research in the area of men's health has been focused on disease events...
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Atraumatic Removal of Displaced Implant in the Fatty Bony Marrow

Sodnom-Ish B, Eo MY, Nguyen TT, Cho YJ, Kim MJ, Kim SM

A 53-year-old Korean female was referred to the Department of Oral and Maxillofacial Surgery at the Seoul National University Dental Hospital. The patient's chief complaint and concern involved the occasional...
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Fracture Experiences and Long-Term Care Initiation among Older Population: Analysis of Korean National Health Insurance Service-Senior Cohort Study

Kim HJ, Jang SN, Lee JK, Ha YC

BACKGROUND: Long-term care is a burden on individuals, families, and society. It is important to find ways to delay the onset of disability to lessen the burden of long-term care...
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Exercise, the Gut Microbiome, and Frailty

Shin HE, Kwak SE, Lee JH, Zhang D, Bae JH, Song W

The gut microbiome is deeply associated with both skeletal muscle and brain function. In particular, gut microbiome dysbiosis may accelerate age-related diseases by affecting these systems. Although there is increasing...
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Pharmacological Interventions for Treatment of Sarcopenia: Current Status of Drug Development for Sarcopenia

Kwak JY, Kwon KS

Sarcopenia, the loss of skeletal muscle mass and function with age, was first recognized as a disease in the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) (M62.84) and...
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