J Korean Med Assoc.  2007 Mar;50(3):208-215. 10.5124/jkma.2007.50.3.208.

Understanding of Aging

• Kwon IS

• KMID: 2184801
• DOI: http://doi.org/10.5124/jkma.2007.50.3.208

Abstract

There is no consensual definition of aging, at present. Aging is said to be all the changes of organism from its birth to death including maturation, development and adulthood and increase of probability of dying with time. And some scientists use senescence as the progressive accumulation of irreversible degenerative changes leading to loss of homeostasis and lack of adaptation to stress to differentiate from aging. Primary or normal aging process is conceptually considered to be universal changes with age, independent of environmental and lifestyle factors. And basic mechanism of intrinsic aging is still unknown. Secondary aging changes include the environmental and disease effects. It is not easy to distinguish normal aging from disease. Successful aging describes high physical, cognitive and social function with no disability and disease. Future research of aging toward successful aging involves study about basic me-chanism of aging with behavioral and societal changes, epidemiologic and clinical research about age related diseases and human longevity study. Identifying factors and interventions will lead to long and healthy human lifespan by delaying of aging process and prevention of disability and the age related diseases.

Keyword

Aging; Normal; Disease; Environment; Healthy longevity

MeSH Terms

Aging*
Homeostasis
Humans
Life Style
Longevity
Parturition

Reference

1. Van de Ven M, Andressoo J, Holcomb VB, Hasty P, Suh Y, van Steeg H, Garinis GA, Hoeijmakers JHJ, Mitchell JR. Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging. Mech Aging Dev. 2007. 128:58–63.

2. Cutler RG, Mattson MP. The adversities of aging. Aging Res Rev. 2006. 221–238.

3. Troen BR. The biology of aging. Mt Sinai J Med. 2003. 70:3–22.

4. Harman D. Aging: Overview. Ann N Y Acad Sci. 2001. 928:1–21.

5. Vijg J, Wei JY. Geriatric bioscience. Understanding the biology of aging: the key to prevention and therapy. JAGS. 1995. 43:426–434.

6. Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci. 2006. 1067:10–21.

7. Kirkwood TBL. Evolution of aging. Mech Aging and Dev. 2002. 123:737–745.

8. In search of the secrets of aging. 1996. NIH Publication;33.

9. Fozard JL, Metter EJ, Brant LJ. Next steps in describing aging and disease in longitudinal studies. J Gerontol Psy Sci. 1990. 45:P116–P127.

10. Rowe JW, Kahn RL. Successful Aging. Gerontologist. 1997. 37:433–440.

11. US Department of Health and Human Services: with the passage of time: The Baltimore Longitudinal Study of Aging. 1993. Washington, DC: Public Health Service; National Institutes of Health;1–52.

12. Fries JF. Aging, natural death, and the compression of morbidity. N Engl J Med. 1980. 303:130–135.

13. Hubert HB, Bloch DA, Oehlert JW, Fries JF. Lifestyle habits and compression of morbidity. J Gerontol A Biol Sci Med Sci. 2002. 57:347–351.

14. Kalache A, Gatti A. Active Aging: a policy framework. Adv Geronntol. 2003. 11:7–18.

15. White House Commission on aging: The road to an aging policy for the 21st century. 1996. Services UDoHaH.

16. Action plan for aging research. Aging N10 U.S. Department of health and human services. 2001.

17. Depp CA, Jeste DV. Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies. Am J Geriatr Psychiatry. 2006. 14:6–20.

18. Hubert HB, Bloch DA, Oehlert JW, Fries JF. Lifestyle habits and compression of morbidity. J Gerontol A Biol Sci Med Sci. 2002. 57:M347–M351.

19. Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: Survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci. 2003. 58:232–237.

20. Perls T, Terry D. Understanding the Determinants of Exceptional Longevity. Ann Intern Med. 2003. 139:445–449.

21. Perls T, Kunkel LM, Puca AA. The genetics of exceptional human longevity. J Am Geriatr Soc. 2002. 50:359–368.

22. Perls T, Wilmoth LM, Levenson R, Drinkwater M, Cohen M, Bogan H, Joyce E, Brewster S, Kunkel L, Puca CC. Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci USA. 2002. 99:8442–8847.

23. Perls T, Levenson R, Regan M, Puca A. What does it take to live to 100. Mech Ageing Dev. 2002. 123:231–242.

24. Masoro EJ. Overview of caloric restriction and aging. Mech Ageing Dev. 2005. 126:913–922.

25. Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller D, Metter EJ. Biomarkers of caloric restriction may predict longevity in humans. Science. 1995. 197:811.

26. Ingram DK, Zhu M, Mamczarz J, Zou S, Lane MA, Roth GS, deCabo R. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006. 5:97–108.

27. Roth GS, Lane MA, Ingram DK. Caloric restriction mimetics: the next phase. Ann N Y Acad Sci. 2005. 1057:365–371.

28. Hadley EC, Rossi WK. Exceptional survival in human population: National Institute on Aging perspectives and programs. Mech Ageing Dev. 2005. 126:231–234.

29. Fries JF. Successful aging-an emerging paradigm of gerontology. Clinics in Geriat Med. 2002. 18:371–382.