Tuberc Respir Dis.  2020 Apr;83(2):107-115. 10.4046/trd.2020.0003.

Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases

  • 1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.


Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our understanding of the molecular mechanisms underlying aging biology has significantly advanced. Interestingly, many of the pivotal molecular features of aging biology are also found to contribute to the pathogenesis of chronic lung disorders such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, for which advanced age is the most crucial risk factor. Thus, an enhanced understanding of how molecular features of aging biology are intertwined with the pathobiology of these aging-related lung disorders has paramount significance and may provide an opportunity for the development of novel therapeutics for these major unmet medical needs. To serve the purpose of integrating molecular understanding of aging biology with pulmonary medicine, in this review, recent findings obtained from the studies of aging-associated lung disorders are summarized and interpreted through the perspective of molecular biology of aging.


Lung Aging; Aging Biology; Pulmonary Disease, Chronic Obstructive; Idiopathic Pulmonary Fibrosis

MeSH Terms

Idiopathic Pulmonary Fibrosis
Molecular Biology
Pulmonary Disease, Chronic Obstructive
Pulmonary Medicine
Risk Factors
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