Yeungnam Univ J Med.  1992 Dec;9(2):342-350. 10.12701/yujm.1992.9.2.342.

Gastric mucosal damage by bile acid

• Cho HH
• Suh JI
• Lee KH
• Kim TN
• Chung MK
• Lee HW
• Choi WH
• Yang CH

• KMID: 2377590
• DOI: http://doi.org/10.12701/yujm.1992.9.2.342

Abstract

To investigate the effect of bile acid on gastric mucosa, we performed biologic test using Sprague-Dawley rat. Mixture solution of TDCA 15mM and Hcl of pH 3 was given into stomach to one group and HCl of pH 3 was given into stomach to another group. The significant gastric mucosal change was vasodilation and edema, that was disappeared progressively. These findings suggest the bile acid and damage gastric mucosa.

Keyword

Stomach; Bile acid; Infalammation

MeSH Terms

Animals
Bile*
Edema
Gastric Mucosa
Hydrogen-Ion Concentration
Rats
Rats, Sprague-Dawley
Stomach
Vasodilation