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Recent Advances in the Diagnosis and Management of Pneumocystis Pneumonia

Tasaka S

In human immunodeficiency virus (HIV)-infected patients, Pneumocystis jirovecii pneumonia (PCP) is a wellk-nown opportunistic infection and its management has been established. However, PCP is an emerging threat to immunocompromised patients...
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Three types of ossifying fibroma: A report of 4 cases with an analysis of CBCT features

Jih MK, Kim JS

Ossifying fibroma is a slow-growing benign neoplasm that occurs most often in the jaws, especially the mandible. The tumor is composed of bone that develops within fibrous connective tissue. Some...
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Rare Cases of PLOD1-Related Kyphoscoliotic Ehlers-Danlos Syndrome in a Korean Family Identified by Next Generation Sequencing

Shin YL, Park YN, Jang MA

Kyphoscoliotic Ehlers-Danlos syndrome (kEDS) is an autosomal recessive connective tissue disorder characterized by muscular hypotonia, hyperextensible skin, skin fragility, joint hypermobility, and progressive kyphoscoliosis. The disorder results from a deficiency...
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Thelazia Callipaeda Infestation with Tarsal Ectropion

Lee YJ, Kim SE, Kim JH, Paik JS, Yang SW

PURPOSE: To report a case of Thelazia callipaeda infestation with tarsal ectropion. CASE SUMMARY: A 79-year-old man presented with epiphora and a sensation of a foreign body in his right eye...
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Dietary nobiletin suppresses TGF-β1-Src-caveolin-1 dependent signaling involved with high glucose-induced renal mesangial matrix accumulation

Kim DY, Kang YH, Kang MK

PURPOSE: Diabetic nephropathy is one of the most important diabetic complications prompted by chronic hyperglycemia, characterized by glomerulosclerosis, tubular fibrosis, and it eventually causes kidney failure. Nobiletin is a polymethoxyflavone...
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Osteogenesis imperfecta and combined orthodontics and orthognathic surgery: a case report on two siblings

Kim DY, Baik U, Jeon JH

Osteogenesis imperfecta is a heterogeneous group of connective tissue diseases that is predominantly characterized by bone fragility and skeletal deformity. Two siblings with undiagnosed type I osteogenesis imperfecta underwent orthognathic...
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Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT

Lin S, Yu L, Ni Y, He L, Weng X, Lu X, Zhang C

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated...
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Evaluation of 2 techniques of epithelial removal in subepithelial connective tissue graft surgery: a comparative histological study

Marques de Mattos P, Papalexiou V, Tramontina VA, Kim SH, Luczyszyn , Bettega PV, Batista Rodrigues Johann AC

PURPOSE: Subepithelial connective tissue grafts (SCTGs) are commonly performed for the treatment of gingival recession due to their high predictability. This study evaluated and histologically compared connective tissue grafts in...
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Diagnosis of Systemic Scleroderma in a Patient with Leg Ulcer

Ju GS, Son KM, Choi WY, Cheon JS

Systemic scleroderma is an autoimmune disease that affects connective tissue in internal organs and the skin with thickening and fibrosis. When afflicting internal organs, the disease leads to reduced quality...
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Effect of melatonin on the onset of puberty in male juvenile rats

Venugopal

Melatonin or N-acetyl-5-methoxytryptamine, the fascinating molecule secreted by the pineal gland. Melatonin has a close interaction with hypothalamic-pituitary-gonadal axis. In non-seasonal breeders like rat its exact role in reproduction is...
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The effects of hard and soft tissue grafting and individualization of healing abutments at immediate implants: an experimental study in dogs

Thoma DS, Jung UW, Gil A, Kim MJ, Paeng KW, Jung RE, Fickl S

PURPOSE: To evaluate the effects of intra-alveolar socket grafting, subepithelial connective tissue grafts, and individualized abutments on peri-implant hard and soft tissue outcomes following immediate implant placement. METHODS: This randomized experimental...
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Ehlers-Danlos syndrome VIII with novel C1R variant accompanying white matter changes

Seo GH, Kim YM, Ghang B, Kim GH, Lee BH

Ehlers-Danlos syndrome (EDS) VIII is an autosomal dominant inherited connective tissue disorder characterized by intractable periodontal inflammation, absence of gingiva, pretibial plaques, skin hyperextensibility, joint hypermobility, and tissue fragility with...
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Chondroid metaplasia of paraspinal connective tissue in the degenerative spine

Stevens S, Agten A, Wisanto E, Monaco ML, Verbrugghe J, Timmermans A, Lambrichts I, Vandenabeele F

A 51-year-old male was routinely biopsied during a paraspinal muscle study. The biopsy sample was taken from the right erector spinae muscle at the fourth lumbar vertebra. The patient had...
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Regulatory Mechanism of MicroRNA-145 in the Pathogenesis of Acute Aortic Dissection

Li T, Liu C, Liu L, Xia H, Xiao Y, Wang X, Wang Y

PURPOSE: Previous studies have confirmed that microRNAs play important roles in the pathogenesis of acute aortic dissection (AAD). Here, we aimed to explore the role of miR-145 and its regulatory...
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Characterization of Tendon-Specific Markers in Various Human Tissues, Tenocytes and Mesenchymal Stem Cells

Jo CH, Lim HJ, Yoon KS

BACKGROUND: Unlike bone, cartilage, or muscle, tendon-specific markers are not well established. The purpose of the study was to investigate expression pattern and level of 6 well-known tendon-specific markers, in...
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Treatment of the wide open wound in the Ehlers-Danlos syndrome

Baik BS, Lee WS, Park KS, Yang WS, Ji SY

Ehlers-Danlos syndrome (EDS) is an inherited disorder of collagen biosynthesis and structure, characterized by skin hyperextensibility, joint hypermobility, aberrant scars, and tissue friability. Besides the skin, skeleton (joint) and vessels,...
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New Diagnostic Guidelines for Idiopathic Pulmonary Fibrosis

Kwon BS, Song JW

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease characterized by worsening lung function and dyspnea. The prognosis of IPF patients is poor, as median survival is approximately...
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Acute Hemodynamic Changes after Single Administration of Udenafil in Pulmonary Arterial Hypertension: a Phase IIa Study

Chang SA, Kim HK, Chang HJ, Kim DK

BACKGROUND AND OBJECTIVES: Udenafil, a new phosphodiesterase-5 inhibitor (PDE5i), has been used to treat erectile dysfunction. Given the proven benefit of PDE5i in pulmonary arterial hypertension (PAH), we evaluated serial...
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Role of Agmatine on Neuroglia in Central Nervous System Injury

Barua S, Kim JY, Lee JE

Recovery from central nervous system (CNS) injury, such as stroke or spinal cord injury (SCI), largely depends on axonal regeneration, and the neuronal and glial cells plasticity in the lesioned...
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The laterally closed tunnel for the treatment of mandibular gingival recession in thin biotype patients: case report

Kim HJ, Kwon EY, Lee JY, Joo JY

In this case report, gingival recession of the mandibular anterior teeth was treated with a laterally closed tunnel technique. Two patients had altered the inclination of mandibular anterior tooth during...
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