Gut Liver.  2014 Jan;8(1):79-87.

Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma

• Kang GH
• Lee BS
• Lee ES
• Kim SH
• Lee HY
• Kang DY

Abstract

BACKGROUND/AIMS
The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival.
METHODS
We analyzed the immunohistochemical expression of p53, mammalian target of rapamycin (mTOR), c-Met, and insulin-like growth factor 1 receptor (IGF-1R) heat shock protein 70 (HSP70) with the clinicopathologic features of 83 HCCs.
RESULTS
p53 expression was higher in the male patients with undifferentiated histological tumor grades, cirrhosis, and portal vein invasion. High 48 c-Met expression correlated with cirrhosis, and high mTOR expression correlated with the tumor grade and cirrhosis. High IGF-1R expression correlated with the tumor grade and cirrhosis. A multivariate analysis identified a significant relationship between the high expression of p53, tumor grade, and portal vein invasion. In addition, a high expression of mTOR was related to tumor grade and cirrhosis, and a high expression of HSP70 was related to portal vein invasion in a multivariate analysis. The Kaplan-Meier survival curve for patients with high versus low Edmondson grades and p53 expression was statistically significant.
CONCLUSIONS
p53, mTOR, and IGF-1R expression correlated with the Edmondson tumor grade in a univariate analysis, while p53 and mTOR correlated with the Edmondson tumor grade in a multivariate analysis. In addition, the tumor grade was found to predict survival. p53 was primarily related to the clinicopathologic features compared to other markers, and it is a poor prognostic factor of survival.

Keyword

p53; mTOR; c-Met; Receptor, IGF type 1; Carcinoma, hepatocellular

MeSH Terms

Adult
Aged
Carcinoma, Hepatocellular/*metabolism/surgery
Disease-Free Survival
Female
HSP70 Heat-Shock Proteins/metabolism
Humans
Liver Neoplasms/*metabolism/surgery
Male
Middle Aged
Prognosis
Proto-Oncogene Proteins c-met/metabolism
Receptor, IGF Type 1/metabolism
Retrospective Studies
Risk Factors
TOR Serine-Threonine Kinases/metabolism
Treatment Outcome
Tumor Markers, Biological/*metabolism
Tumor Suppressor Protein p53/metabolism
HSP70 Heat-Shock Proteins
Proto-Oncogene Proteins c-met
Receptor, IGF Type 1
TOR Serine-Threonine Kinases
Tumor Markers, Biological
Tumor Suppressor Protein p53