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MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts

Zhang C, Dai J, Fan Y, He X, Wei R

BACKGROUND/AIMS: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. METHODS: Primary human dermal fibroblasts were separated from normal human skin samples....
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Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction

Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM

The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide...
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Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains

Farahtaj F, Alizadeh L, Gholami A, Tahamtan A, Shirian S, Fazeli M, Nejad AS, Gorji A, Niknam HM, Ghaemi A

OBJECTIVES: Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying...
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Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus

Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW

In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into...
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Role of Immunosuppressive Microenvironment in Acquiring Immunotolerance Post-Photothermal Therapy

Cherukula , Park MS, Sontyana A, Mathew AP, Vijayan V, Bae WK, Park IK

BACKGROUND: Nanoparticle-mediated photothermal therapy (PTT) has been well studied as a treatment for cancer. However, the therapeutic outcome of PTT is often hindered by the penetration depth of laser light....
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S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion

Choi JI, Ha SK, Lim DJ, Kim SD, Kim SH

OBJECTIVE: Diagnosing acute cerebral infarction is crucial in determining prognosis of stroke patients. Although many serologic tests for prompt diagnosis are available, the clinical application of serologic tests is currently...
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Immediate Effects of a Single Exercise on Behavior and Memory in the Early Period of Traumatic Brain Injury in Rats

Yoon KJ, Kim DY

OBJECTIVE: To evaluate the immediate effect of single exercise on physical performance and memory in the early stage of traumatic brain injury (TBI) in rats. METHODS: Ninety TBI rats were randomly...
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Gene Therapy for Hearing Protection

Lee MY

Sensorineural hearing loss (SNHL) does not recover and only few exceptions exist. It is mostly due to the reason that hair cells in the cochlea cannot regenerate once damaged. Therefore,...
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Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid

Yoo K, Suh KY, Choi GH, Kwak IS, Seo DK, Kym D, Yoon H, Cho YS, Kim HO

BACKGROUND: It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no...
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Potential Vaccine Targets against Rabbit Coccidiosis by Immunoproteomic Analysis

Song H, Dong R, Qiu B, Jing J, Zhu S, Liu C, Jiang Y, Wu L, Wang S, Miao J, Shao Y

The aim of this study was to identify antigens for a vaccine or drug target to control rabbit coccidiosis. A combination of 2-dimensional electrophoresis, immunoblotting, and mass spectrometric analysis were...
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Expression of CAIII and Hsp70 Is Increased the Mucous Membrane of the Posterior Commissure in Laryngopharyngeal Reflux Disease

Min HJ, Hong SC, Yang HS, Mun SK, Lee SY

PURPOSE: We tried to evaluate the difference in the expression of carbonic anhydrase (CA) III and heat shock protein (Hsp) 70 between laryngopharyngeal reflux disease (LPRD) and non-LPRD patients. MATERIALS AND...
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The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression

Choi DW, Lim MS, Lee JW, Chun W, Lee SH, Nam YH, Park JM, Choi DH, Kang CD, Lee SJ, Park SC

Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins...
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Differentially Expressed Proteins in Nitric Oxide-Stimulated NIH/3T3 Fibroblasts: Implications for Inhibiting Cancer Development

Shim DH, Lim JW, Kim H

PURPOSE: Recent evidence shows that nitric oxide (NO) may exhibit both pro-cancer and anti-cancer activities. The present study aimed to determine the differentially expressed proteins in NO-treated NIH/3T3 fibroblasts in...
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Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts

Shin JU, Lee WJ, Tran TN, Jung I, Lee JH

PURPOSE: There are currently no consistently effective treatments for the excessive collagen produced by keloid fibroblasts. Previously, we reported that heat shock protein 70 (Hsp70) is up-regulated in keloid fibroblasts...
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The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis

Wang XW, Shi XH, Tong YS, Cao XF

PURPOSE: Heat shock proteins (HSPs) are highly conserved molecular chaperones. There are various studies that assess the prognostic value of HSPs in patients with esophageal cancer, but the conclusion remains...
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The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer

Kang HJ, Moon HS, Chung HW

OBJECTIVE: In this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation...
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Semi-Quantitative Analyses of Hippocampal Heat Shock Protein-70 Expression Based on the Duration of Ischemia and the Volume of Cerebral Infarction in Mice

Choi JI, Kim SD, Kim SH, Lim DJ, Ha SK

OBJECTIVE: We investigated the expression of hippocampal heat shock protein 70 (HSP-70) infarction volume after different durations of experimental ischemic stroke in mice. METHODS: Focal cerebral ischemia was induced in mice...
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Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos

Cho J, Kang S, Lee BC

This study was conducted to investigate the expression of three genes related to early embryonic development in bovine transgenic cloned embryos. To accomplish this, development of bovine transgenic somatic cell...
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Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma

Kang GH, Lee BS, Lee ES, Kim SH, Lee HY, Kang DY

  • KMID: 1774532
  • Gut Liver.
  • 2014 Jan;8(1):79-87.
BACKGROUND/AIMS: The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival. METHODS: We...
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Prognostic Significance of Heat Shock Protein 70 Expression in Early Gastric Carcinoma

Kang Y, Jung WY, Lee H, Jung W, Lee E, Shin BK, Kim A, Kim HK, Kim BH

  • KMID: 2277438
  • Korean J Pathol.
  • 2013 Jun;47(3):219-226.
BACKGROUND: Overexpression of heat shock protein 70 (HSP70) has been observed in many types of cancer including gastric adenocarcinomas, although the exact role of HSP70 in carcinogenesis remains unclear. METHODS: The...
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