Korean J Pathol.  2013 Jun;47(3):219-226.

Prognostic Significance of Heat Shock Protein 70 Expression in Early Gastric Carcinoma

• Kang Y
• Jung WY
• Lee H
• Jung W
• Lee E
• Shin BK
• Kim A
• Kim HK
• Kim BH

Abstract

BACKGROUND
Overexpression of heat shock protein 70 (HSP70) has been observed in many types of cancer including gastric adenocarcinomas, although the exact role of HSP70 in carcinogenesis remains unclear.
METHODS
The study analyzed a total of 458 radical gastrectomy specimens which were immunohistochemically stained with HSP70, p53, and Ki-67 antibodies.
RESULTS
The study determined that the expression of HSP70 was significantly increased in early gastric cancer (EGC) compared to advanced gastric cancer (p<0.001). The HSP70 expression was correlated with well-differentiated tumor type, intestinal type of Lauren classification and the lower pT and pN stage. Negative expression of Ki-67 and p53 expression was associated with poor prognosis. The study did not find any correlation between HSP70 and p53 expression. The study determined that HSP70 expression in the EGC subgroup was associated with a poor prognosis (p=0.009), as well as negative Ki-67 expression (p=0.006), but was not associated with p53. Based on multivariate analysis, HSP70 expression (p=0.024), negative expression of Ki-67, invasion depth and lymph node metastasis were determined to be independent prognostic markers.
CONCLUSIONS
HSP70 is expressed in the early stages of gastric adenocarcinoma. In EGC, HSP70 is a poor independent prognostic marker and is correlated with a low proliferation index.

Keyword

HSP70 heat-shock proteins; Ki-67 antigen; Early gastric carcinoma

MeSH Terms

Adenocarcinoma
Gastrectomy
Heat-Shock Proteins
Hot Temperature
HSP70 Heat-Shock Proteins
Ki-67 Antigen
Lymph Nodes
Multivariate Analysis
Neoplasm Metastasis
Prognosis
Stomach Neoplasms
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Ki-67 Antigen