- Alternative Polyadenylation in Human Diseases
-
Chang JW, Yeh HS, Yong J
- KMID: 2406184
- Endocrinol Metab.
- 2017 Dec;32(4):413-421.
- doi: 10.3803/EnM.2017.32.4.413
Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as... -
- CITED
-
- Close
- SHARE
-
- Close
- Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast
-
Shin CS, Chang YJ, Lee HG, Huh WK
- KMID: 2166467
- Genomics Inform.
- 2009 Dec;7(4):203-207.
The target of rapamycin (TOR) signaling pathway conserved from yeast to human plays critical roles in regulation of eukaryotic cell growth. It has been shown that TOR pathway is involved... -
- CITED
-
- Close
- SHARE
-
- Close
- Mechanisms of amino acid sensing in mTOR signaling pathway
-
Kim E
- KMID: 2313379
- Nutr Res Pract.
- 2009 Mar;3(1):64-71.
Amino acids are fundamental nutrients for protein synthesis and cell growth (increase in cell size). Recently, many compelling evidences have shown that the level of amino acids is sensed by... -
- CITED
-
- Close
- SHARE
-
- Close
- Melanoma Cell Death Mechanisms
-
Broussard , Howland A, Ryu S, Song K, Norris D, Armstrong , Song PI
- KMID: 2420880
- Chonnam Med J.
- 2018 Sep;54(3):135-142.
- doi: 10.4068/cmj.2018.54.3.135
Over recent years, several new molecular and immunogenic therapeutic approaches to melanoma treatment have been approved and implemented in clinical practice. Mechanisms of resistance to these new therapies have become... -
- CITED
-
- Close
- SHARE
-
- Close
- Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia
-
Park JA, Lee CH
- KMID: 2412582
- J Vet Sci.
- 2017 Mar;18(1):11-16.
- doi: 10.4142/jvs.2017.18.1.11
Mammalian target of rapamycin (mTOR) has an important role in various biological processes in cells. In the present study, we investigated temporal changes in mTOR and phosphorylated-mTOR (p-mTOR) expressions in... -
- CITED
-
- Close
- SHARE
-
- Close
- Dual Inhibition of PI3K/Akt/mTOR Pathway and Role of Autophagy in Non-Small Cell Lung Cancer Cells
-
Jeong EH, Choi HS, Lee TG, Kim HR, Kim CH
- KMID: 2319806
- Tuberc Respir Dis.
- 2012 Apr;72(4):343-351.
BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling axis has emerged as a novel target for cancer therapy. Agents that inhibit this pathway are currently under development for... -
- CITED
-
- Close
- SHARE
-
- Close
- Current Status of Molecular Targeted Therapies in Hepatocellular Carcinoma
-
Suh SJ, Yim HJ
- KMID: 1501636
- Korean J Gastroenterol.
- 2013 Mar;61(3):136-146.
- doi: 10.4166/kjg.2013.61.3.136
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in Korea. Curative treatment is only possible when the disease is diagnosed at the early stage. The prognosis... -
- CITED
-
- Close
- SHARE
-
- Close
- Efficacy and Toxicity of Mammalian Target Rapamycin Inhibitors in Patients with Metastatic Renal Cell Carcinoma with Renal Insufficiency: The Korean Cancer Study Group GU 14-08
-
Kim KH, Kim JH, Lee JY, Kim HS, Heo SJ, Kim JH, Kim HY, Rha SY
- KMID: 2356230
- Cancer Res Treat.
- 2016 Oct;48(4):1286-1292.
- doi: 10.4143/crt.2016.018
PURPOSE: We evaluated the efficacy and toxicity of mammalian target rapamycin inhibitors in Korean patients with metastatic renal cell carcinoma (mRCC) with chronic renal insufficiency not requiring dialysis. MATERIALS AND METHODS:... -
- CITED
-
- Close
- SHARE
-
- Close
- Crizotinib in Combination with Everolimus Synergistically Inhibits Proliferation of Anaplastic Lymphoma Kinase‒Positive Anaplastic Large Cell Lymphoma
-
Xu W, Kim JW, Jung WJ, Koh Y, Yoon SS
- KMID: 2411148
- Cancer Res Treat.
- 2018 Apr;50(2):599-613.
- doi: 10.4143/crt.2016.357
PURPOSE: Anaplastic large cell lymphoma (ALCL) is a rare aggresive non-Hodgkin lymphoma, of which over 50% of cases have an aberrant nucleophosmin (NPM)‒anaplastic lymphoma kinase (ALK) fusion protein. Both mechanistic... -
- CITED
-
- Close
- SHARE
-
- Close
- Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy
-
Lee SC, Kim KH, Kim OH, Lee SK, Hong HE, Choi BJ, Jeong W, Kim SJ
- KMID: 2417890
- Cancer Res Treat.
- 2018 Jul;50(3):1023-1038.
- doi: 10.4143/crt.2017.085
PURPOSE: Everolimus only inhibits mammalian target of rapamycin complex 1 (mTORC1), whereas Ku0063794 inhibits both mTORC1 and mTORC2. Although they have similar anticancer effects, their combination has a synergistic effect... -
- CITED
-
- Close
- SHARE
-
- Close
- Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?
-
Tran P, Nguyen C, Klempner S
- KMID: 2362506
- Int Neurourol J.
- 2016 Nov;20(Suppl 2):S131-S140.
- doi: 10.5213/inj.1632740.370
Phosphatidylinositol-3-kinase (PI3K) pathway signaling is an established oncogenic signal transduction pathway implicated in multiple malignancies. Therapeutic targeting of PI3K pathway components has improved outcomes in chronic lymphocytic leukemia, kidney cancer,... -
- CITED
-
- Close
- SHARE
-
- Close
- Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells
-
Choi HS, Jeong EH, Lee TG, Kim SY, Kim HR, Kim CH
- KMID: 2320432
- Tuberc Respir Dis.
- 2013 Jul;75(1):9-17.
BACKGROUND: In cancer cells, autophagy is generally induced as a pro-survival mechanism in response to treatment-associated genotoxic and metabolic stress. Thus, concurrent autophagy inhibition can be expected to have a... -
- CITED
-
- Close
- SHARE
-
- Close
- Regulation of paclitaxel-induced programmed cell death by autophagic induction: A model for cervical cancer
-
Chi EY, Viriyapak , Kwack HS, Lee YK, Kim SI, Lee KH, Park TC
- KMID: 1425655
- Obstet Gynecol Sci.
- 2013 Mar;56(2):84-92.
- doi: 10.5468/OGS.2013.56.2.84
OBJECTIVE: Autophagy plays a vital role in homeostasis by combining organelles and cellular proteins with lysosome under starvation conditions. In addition, autophagy provides tumor cells with a source of energy.... -
- CITED
-
- Close
- SHARE
-
- Close
- Trichomonas vaginalis Metalloproteinase Induces mTOR Cleavage of SiHa Cells
-
Quan JH, Choi IW, Yang JB, Zhou W, Cha GH, Zhou Y, Ryu JS, Lee YH
- KMID: 2069809
- Korean J Parasitol.
- 2014 Dec;52(6):595-603.
- doi: 10.3347/kjp.2014.52.6.595
Trichomonas vaginalis secretes a number of proteases which are suspected to be the cause of pathogenesis; however, little is understood how they manipulate host cells. The mammalian target of rapamycin... -
- CITED
-
- Close
- SHARE
-
- Close
- Current Status of Targeted Therapy for Advanced Renal Cell Carcinoma
-
Cho IC, Chung J
- KMID: 2315382
- Korean J Urol.
- 2012 Apr;53(4):217-228.
The treatment of metastatic renal cell carcinoma (mRCC) has recently evolved from being predominantly cytokine-based treatment to the use of targeted agents, which include sorafenib, sunitinib, bevacizumab (plus interferon alpha... -
- CITED
-
- Close
- SHARE
-
- Close
- Rapamycin Inhibits Transforming Growth Factor beta1-Induced Fibrogenesis in Primary Human Lung Fibroblasts
-
Gao Y, Xu X, Ding K, Liang Y, Jiang D, Dai H
- KMID: 1503908
- Yonsei Med J.
- 2013 Mar;54(2):437-444.
- doi: 10.3349/ymj.2013.54.2.437
PURPOSE: The present study was designed to determine whether rapamycin could inhibit transforming growth factor beta1 (TGF-beta1)-induced fibrogenesis in primary lung fibroblasts, and whether the effect of inhibition would occur... -
- CITED
-
- Close
- SHARE
-
- Close
- Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons
-
Choi S, Sadra A, Kang J, Ryu JR, Kim JH, Sun W, Huh SO
- KMID: 2450212
- Exp Neurobiol.
- 2019 Apr;28(2):172-182.
- doi: 10.5607/en.2019.28.2.172
Rheb (Ras homolog enriched in the brain) is a small GTPase protein that plays an important role in cell signaling for development of the neocortex through modulation of mTORC1 (mammalian-target-of-rapamycin-complex-1)... -
- CITED
-
- Close
- SHARE
-
- Close
- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
-
Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
- CITED
-
- Close
- SHARE
-
- Close
- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
-
Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
- CITED
-
- Close
- SHARE
-
- Close
- Estrogen deprivation and excess energy supply accelerate 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in C3H/HeN mice
-
Kim J, Lee YH, Park JH, Sung MK
- KMID: 2313887
- Nutr Res Pract.
- 2015 Dec;9(6):628-636.
- doi: 10.4162/nrp.2015.9.6.628
BACKGROUND/OBJECTIVES: Obesity is a risk factor of breast cancer in postmenopausal women. Estrogen deprivation has been suggested to cause alteration of lipid metabolism thereby creating a cellular microenvironment favoring tumor... -
- CITED
-
- Close
- SHARE
-
- Close
