- Lipopolysaccharide-induced Autophagy Increases SOX2-positive Astrocytes While Decreasing Neuronal Differentiation in the Adult Hippocampus
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Liu WC, Wu CW, Fu MH, Tain YL, Liang CK, Chen IC, Hung CY, Lee YC, Wu KL
- KMID: 2535062
- Exp Neurobiol.
- 2022 Oct;31(5):307-323.
- doi: 10.5607/en22005
Inflammation alters the neural stem cell (NSC) lineage from neuronal to astrogliogenesis. However, the underlying mechanism is elusive. Autophagy contributes to the decline in adult hippocampal neurogenesis under E. coli... -
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- Recent Update in Pharmacological Agents for Optic Pathway Glioma
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Park M
- KMID: 2529441
- Brain Tumor Res Treat.
- 2022 Apr;10(2):101-107.
- doi: 10.14791/btrt.2022.0006
Optic pathway gliomas (OPGs) are insidious, debilitating low-grade tumors. They can affect the optic nerve, optic chiasm, and optic tracts and can be sporadic or associated with neurofibromatosis type 1... -
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- Efficacy of the Ketogenic Diet for Pediatric Epilepsy According to the Presence of Detectable Somatic mTOR Pathway Mutations in the Brain
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Ko A, Sim NS, Choi HS, Yang D, Kim SH, Lee JS, Kim DS, Lee JH, Kim HD, Kang HC
- KMID: 2524555
- J Clin Neurol.
- 2022 Jan;18(1):71-78.
- doi: 10.3988/jcn.2022.18.1.71
Background and Purpose A multifactorial antiepileptic mechanism underlies the ketogenic diet (KD), and one of the proposed mechanisms of action is that the KD inhibits the mammalian target of rapamycin... -
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- Potentiation of the Anticancer Effects by Combining Docetaxel with Ku-0063794 against Triple-Negative Breast Cancer Cells
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Jeon YW, Kim OH, Shin JS, Hong HE, Kim CH, Kim SJ
- KMID: 2524597
- Cancer Res Treat.
- 2022 Jan;54(1):157-173.
- doi: 10.4143/crt.2020.1063
Purpose mTORC1 and mTORC2 inhibition by Ku-0063794 could confer profound anticancer effects against cancer cells because it eliminates feedback activation of Akt. Herein, we aimed to determine anticancer effects of... -
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- AR-mTOR-SRF Axis Regulates HMMR Expression in Human Prostate Cancer Cells
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Sun Y, Li Z, Song K
- KMID: 2522255
- Biomol Ther.
- 2021 Nov;29(6):667-677.
- doi: 10.4062/biomolther.2021.040
The elevated expression of the hyaluronan-mediated motility receptor (HMMR) is known to be highly associated with tumor progression in prostate cancer, but the molecular mechanisms underlying the regulation of HMMR... -
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- Dioscin Decreases Breast Cancer Stem-like Cell Proliferation via Cell Cycle Arrest by Modulating p38 Mitogen-activated Protein Kinase and AKT/mTOR Signaling Pathways
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Chae WO, Kim GD
- KMID: 2521105
- J Cancer Prev.
- 2021 Sep;26(3):183-194.
- doi: 10.15430/JCP.2021.26.3.183
Dioscin (DS), a steroidal saponin, has been shown to have anti-cancer activity by exerting antioxidant effects and inducing apoptosis. However, the anti-cancer activity of DS in breast cancer-derived stem cells... -
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- Rapamycin reduces orofacial nociceptive responses and microglial p38 mitogen-activated protein kinase phosphorylation in trigeminal nucleus caudalis in mouse orofacial formalin model
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Yeo JH, Kim SJ, Roh DH
- KMID: 2516875
- Korean J Physiol Pharmacol.
- 2021 Jul;25(4):365-374.
- doi: 10.4196/kjpp.2021.25.4.365
The mammalian target of rapamycin (mTOR) plays a role in various cellular phenomena, including autophagy, cell proliferation, and differentiation. Although recent studies have reported its involvement in nociceptive responses in... -
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- Cryptotanshinone Prevents the Binding of S6K1 to mTOR/Raptor Leading to the Suppression of mTORC1-S6K1 Signaling Activity and Neoplastic Cell Transformation
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Jeoung NH, Jeong JY, Kang BS
- KMID: 2517366
- J Cancer Prev.
- 2021 Jun;26(2):145-152.
- doi: 10.15430/JCP.2021.26.2.145
Cryptotanshinone is known for its inhibitory activity against tumorigenesis in various human cancer cells. However, exact mechanisms underlying the anticancer effects of cryptotanshinone are not fully elucidated. Here, we propose... -
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- An Unusual Case of Colon Perforation With Multiple Transmural Ulcers After Use of Polmacoxib and Everolimus in a Metastatic Breast Cancer Patient
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Song IG, Jung KU, Kim HO, Kim H, Chun HK
- KMID: 2515377
- Ann Coloproctol.
- 2021 Apr;37(2):120-124.
- doi: 10.3393/ac.2019.08.17
Everolimus (Afinitor) is an inhibitor of mammalian target of rapamycin. Polmacoxib (Acelex) is a nonsteroidal anti-inflammatory drug that belongs to the cyclooxygenase-2 (COX-2) inhibitor family and is mainly used for... -
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- Effects of Aging on Angiogenic and Muscle Growth-Related Factors in Naturally Aged Rat Skeletal Muscles
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Yeo HS, Lim JY, Ahn NY
- KMID: 2509932
- Ann Geriatr Med Res.
- 2020 Dec;24(4):305-312.
- doi: 10.4235/agmr.20.0077
Background This study explored the effects of aging on the expression of angiogenic and muscle protein synthesis factors, as well as the number of satellite cells affecting sarcopenia in naturally aged... -
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- Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents
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Oh JY, Liu QF, Hua C, Jeong HJ, Jang JH, Jeon S, Park HJ
- KMID: 2510507
- Exp Neurobiol.
- 2020 Dec;29(6):453-469.
- doi: 10.5607/en20024
Major depressive disorder is a complex neuropsychiatric disorder with few treatment options. Non-targeted antidepressants have low efficacy and can induce series of side effects. While a neuropeptide, melanin-concentrating hormone (MCH),... -
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- Autophagy and liver cancer
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Chao X, Qian H, Wang S, Fulte S, Ding WX
- KMID: 2507981
- Clin Mol Hepatol.
- 2020 Oct;26(4):606-617.
- doi: 10.3350/cmh.2020.0169
Autophagy is a highly conserved catabolic process that degrades cytosolic proteins and organelles via formation of autophagosomes that fuse with lysosomes to form autolysosomes, whereby autophagic cargos are degraded. Numerous... -
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- Smith-Kingsmore syndrome: The first report of a Korean patient with the MTOR germline mutation c.5395G>A p.(Glu1799Lys)
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Lee D, Jang JH, Lee CG
- KMID: 2451624
- J Genet Med.
- 2019 Jun;16(1):27-30.
- doi: 10.5734/JGM.2019.16.1.27
Smith-Kingsmore syndrome (SKS; OMIM 616638), also known as macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome (MINDS; ORPHA 457485), is a rare autosomal dominant disorder, the prevalence of which is not known. It... -
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- Mechanistic Target of Rapamycin Pathway in Epileptic Disorders
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Kim JK, Lee JH
- KMID: 2453232
- J Korean Neurosurg Soc.
- 2019 May;62(3):272-287.
- doi: 10.3340/jkns.2019.0027
The mechanistic target of rapamycin (mTOR) pathway coordinates the metabolic activity of eukaryotic cells through environmental signals, including nutrients, energy, growth factors, and oxygen. In the nervous system, the mTOR... -
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- Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons
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Choi S, Sadra A, Kang J, Ryu JR, Kim JH, Sun W, Huh SO
- KMID: 2450212
- Exp Neurobiol.
- 2019 Apr;28(2):172-182.
- doi: 10.5607/en.2019.28.2.172
Rheb (Ras homolog enriched in the brain) is a small GTPase protein that plays an important role in cell signaling for development of the neocortex through modulation of mTORC1 (mammalian-target-of-rapamycin-complex-1)... -
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- NLRC3 Attenuates Colon Cancer by Down-Regulating PI3K-mTOR Signaling
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Ali I, Koh YS
- KMID: 2414857
- J Bacteriol Virol.
- 2018 Jun;48(2):67-71.
- doi: 10.4167/jbv.2018.48.2.67
The nucleotide-binding oligomerization domain-like receptors (NOD-like receptors, NLRs) are intracellular sensors. Most of them positively affect inflammatory responses, particularly the inflammasome forming NLRs. On the other hand, several studies on... -
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- Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway
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Zhou W, Quan JH, Gao FF, Ismail HA, Lee YH, Cha GH
- KMID: 2412732
- Korean J Parasitol.
- 2018 Apr;56(2):135-145.
- doi: 10.3347/kjp.2018.56.2.135
Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little... -
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- Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage
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Park JA, Lee CH
- KMID: 2429050
- Biomol Ther.
- 2018 Mar;26(2):115-120.
- doi: 10.4062/biomolther.2016.248
Chronic cerebral hypoperfusion (CCH), which is associated with onset of vascular dementia, causes cognitive impairment and neuropathological alterations in the brain. In the present study, we examined the neuroprotective effect... -
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- Identification of Downstream Genes of the mTOR Pathway that Predict Recurrence and Progression in Non-Muscle Invasive High-Grade Urothelial Carcinoma of the Bladder
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Jin S, Chang IH, Kim JW, Whang YM, Kim HJ, Hong SA, Lee TJ
- KMID: 2439468
- J Korean Med Sci.
- 2017 Aug;32(8):1327-1336.
- doi: 10.3346/jkms.2017.32.8.1327
Microarray analysis was used to investigate the lack of identified mammalian target of rapamycin (mTOR) pathway downstream genes to overcome cross-talk at non-muscle invasive high-grade (HG)-urothelial carcinoma (UC) of the... -
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- NBR1 and KIF14 Downstream of the Mammarian Target of Rapamycin Pathway Predict Recurrence in Nonmuscle Invasive Low Grade Urothelial Carcinoma of the Bladder
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Lee DG, Kim HJ, Jin S, Kim JW, Whang YM, Lee TJ, Chang IH
- KMID: 2379757
- Korean J Urol Oncol.
- 2017 Apr;15(1):28-37.
- doi: 10.22465/kjuo.2017.15.1.28
PURPOSE: The lack of identified mammalian target of rapamycin (mTOR) pathway downstream genes that overcome cross-talk in nonmuscle invasive low grade (LG)-urothelial carcinoma (UC) of the bladder is a clinical... -
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