Korean J Obstet Gynecol.  2009 Jun;52(6):631-635.

Declining concentrations of dehydroepiandrosterone sulfate and free testosterone with advancing age

• Han MS
• Choi IJ

Abstract

OBJECTIVE
To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) or free testosterone (FT) levels and aging.
METHODS
One hundred and thirty one women without androgen excess symptoms such as oligomenorrhea or amenorrhea or hirsutism were recruited for measuring serum DHEAS, FT levels by radioimmunoassay. A P-value <0.05 was considered to be significant statistically.
RESULTS
The levels of DHEAS were 211.39+/-33.01 microg/dL (twenties, n=10), 127.99+/-11.79 microg/dL (thirties, n=31), 94.30+/-7.49 microg/dL (forties, n=57) and 71.79+/-5.71 microg/dL (over fifties, n=33) respectively (mean+/-SE, P<0.001). The levels of FT were 3.98+/-0.94 pg/ml (twenties, n=10), 3.37+/-0.47 pg/mL (thirties, n=31), 2.68+/-0.30 pg/mL (forties, n=57) and 1.97+/-0.28 pg/mL (fifties, n=33) respectively (mean+/-SE, P=0.030). Mean value declining of DHEAS (r=-0.48865, P<0.0001) was bigger than those of FT (r=-0.29334, P<0.0007).
CONCLUSION
Both DHEAS and FT levels decline with age and DHEAS decreases more steeply than FT.

Keyword

Dehydroepiandrosterone sulfate; Testosterone; Aging

MeSH Terms

Aging
Amenorrhea
Dehydroepiandrosterone
Dehydroepiandrosterone Sulfate
Female
Hirsutism
Humans
Oligomenorrhea
Radioimmunoassay
Testosterone
Dehydroepiandrosterone
Dehydroepiandrosterone Sulfate
Testosterone