Korean J Vet Res.
2017 Mar;57(1):47-50. 10.14405/kjvr.2017.57.1.47.
Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs
- Affiliations
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- 1Department of Comparative Biomedicine and Food Sciences, University of Padova, Legnaro 35020, Italy. paolo.mongillo@unipd.it
- 2Department of Animal Medicine, Production and Health, University of Padova, Legnaro 35020, Italy.
- 3Portoni Rossi Veterinary Hospital, Zola Predosa 40069, Italy.
- KMID: 2376879
- DOI: http://doi.org/10.14405/kjvr.2017.57.1.47
Abstract
- Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.
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