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Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain

Choi SR, Beitz AJ, Lee JH

We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory...
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Estrogen-secreting adrenocortical carcinoma

Jeong Y, Cho SC, Cho HJ, Song JS, Kong JS, Park JW, Ku YH

Adrenocortical carcinoma is a rare type of endocrine malignancy with an annual incidence of approximately 1–2 cases per million. The majority of these tumors secrete cortisol, and a few secrete...
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The association between serum dehydroepiandrosterone sulfate (DHEAS) levels and job-related stress among female nurses

Cho S, Park WJ, Kang W, Lim HM, Ahn JS, Lim DY, Moon JD

BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is an endogenous steroid hormone produced by the adrenal gland. DHEAS has been suggested to play a protective role against psychosocial stress. The aim of this...
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Association between Body Mass Index and Serum Dehydroepiandrosterone Sulfate Level in 8-Year-Old Girls

Na JH, Kim YH, Hong SJ, Kim JK

BACKGROUND: Adiposity may play a role as a potential trigger for adrenarche. The purpose of this study was to evaluate the association between body mass index (BMI) and serum dehydroepiandrosterone...
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The association between skeletal maturation and adrenal androgen levels in obese children and adolescents

Kim SE, Jang JW, Ahn MB, Kim SH, Cho WK, Cho KS, Park SH, Jung MH, Suh BK

PURPOSE: This study aimed to investigate the association between skeletal maturation and adrenal androgen levels in obese children and adolescents. METHODS: Fifty-three children and adolescents (aged 7–15 years) diagnosed as obese...
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Dehydroepiandrosterone Sulfate Level Varies Nonlinearly with Symptom Severity in Major Depressive Disorder

Uh D, Jeong HG, Choi KY, Oh SY, Lee S, Kim SH, Joe SH

OBJECTIVE: The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate biomarkers in MDD have been reported, which might be a consequence of the...
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The Association between Dehydroepiandrosterone Sulfate (DHEA-S) and Bone Mineral Density in Korean Men and Women

Park SG, Hwang S, Kim JS, Park KC, Kwon Y, Kim KC

BACKGROUND: The relationship between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density (BMD) is controversial. And findings of most studies that have investigated this relationship are restricted to postmenopausal women. In...
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Etiology and therapeutic outcomes of children with gonadotropin-independent precocious puberty

Kang E, Cho JH, Choi JH, Yoo HW

PURPOSE: This study was performed to investigate the etiology, clinical features, and outcomes of patients with gonadotropin-independent precocious puberty (GIPP). METHODS: The study included 16 patients (14 female and 2 male...
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Limited Diagnostic Utility of Plasma Adrenocorticotropic Hormone for Differentiation between Adrenal Cushing Syndrome and Cushing Disease

Hong AR, Kim JH, Hong ES, Kim IK, Park KS, Ahn CH, Kim SW, Shin CS, Kim SY

BACKGROUND: Measurement of the plasma adrenocorticotropic hormone (ACTH) level has been recommended as the first diagnostic test for differentiating between ACTH-independent Cushing syndrome (CS) and ACTH-dependent CS. When plasma ACTH...
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The Relationship between Opioids Use, Cortisol and DHEAS

Jung JH, Choi YS, Kim SM, Lee JY, Kim EH, Kim JE, Kim EY, Park HJ, Yoon DJ

PURPOSE: Fatigue, energy loss, feeling of helplessness, poor appetite, pain besides general weakness are major symptoms presented to terminally ill cancer patients. These symptoms are similar to those that appeared...
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Dehydroepiandrosterone Sulfate as a Risk Factor for Premature Myocardial Infarction: A Comparative Study

Shojaie M, Rajpout MY, Abtahian A, Pour AE, Ghobadifar MA, Akbarzadeh A

BACKGROUND: This study aimed to evaluate some of the major risk factors of myocardial infarction including dehydroepiandrosterone sulfate in patients with premature myocardial infarction (age or =50 years). METHODS: This...
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Effects of Long-term Administration of the Antiaging Hormone Dehydroepiandrosterone Sulfate on Rat Prostates and Testes as Androgen-Dependent Organs

Sah C, Aridogan I, Izol V, Erdogan S, Doran S

  • KMID: 2430623
  • Korean J Urol.
  • 2013 Mar;54(3):199-203.
PURPOSE: This study aimed to determine the effects of the long-term use of dehydroepiandrosterone sulfate (DHEAS) on rat prostates and testes as well as on serum testosterone and DHEAS levels. MATERIALS...
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A Case of adrenocortical oncocytoma Presenting with Peripheral Precocious Puberty

Oh SH, Jung CW, Lee J, Lee BH, Kim DY, No DY, Yoo SH, Choi JH, Yoo HW

Adrenocortical oncocytoma is a rare adrenal gland tumor, and in most cases, benign and non-functioning. Functional adrenocortical oncocytoma has only been reported in eleven cases worldwide, including three children. These...
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A Adrenocortical Oncocytoma in a 10-year-old Girl Presenting with Virilization

Eom TM, Kim MK, Lee SH, Chung WY, Park JK, Jung SJ, Shin JH

  • KMID: 2049284
  • Clin Pediatr Hematol Oncol.
  • 2012 Oct;19(2):128-131.
Adrenocortical oncocytoma is a rare epithelial tumor only described in adults and in most cases, benign and non-functioning. Histologically characterized by cells with eosinophilic granular cytoplasm and ultra-structurally by the...
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Correlation of Occupational Stress Index with 24-hour Urine Cortisol and Serum DHEA Sulfate among City Bus Drivers: A Cross-sectional Study

Du CL, Lin MC, Lu L, Tai JJ

  • KMID: 2317012
  • Saf Health Work.
  • 2011 Jun;2(2):169-175.
OBJECTIVES: The questionnaire of occupational stress index (OSI) has been popular in the workplace, and it has been tailored for bus drivers in Taiwan. Nevertheless, its outcomes for participants are...
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Role of Sigma Receptor and Neurosteroids in Pain Sensation

Lee JH

The sigma-1 receptor has recently been implicated in a myriad of cellular functions and biological processes. Previous studies have demonstrated that the spinal sigma-1 receptor plays a pro-nociceptive role in...
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Amenorrhea and Bone Mineral Density in Premenopausal Women

Kim SR, Kang BM, Jeon GH, Kim SH, Chae HD, Kim CH

  • KMID: 2189020
  • J Korean Soc Osteoporos.
  • 2010 Apr;8(1):38-46.
OBJECTIVES: This study was designed to investigate the prevalence of low bone mass and to evaluate the influence of amenorrhea on bone mineral density (BMD) in premenopausal women. METHODS: One hundred...
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Adrenocortical Carcinoma in a Patient with Congenital Adrenal Hyperplasia

Cho MS, Jin HY, Choi JH, Kim DY, Lee JJ, Yoo HW

  • KMID: 2192851
  • J Korean Soc Pediatr Endocrinol.
  • 2010 Dec;15(3):193-197.
Adrenocortical carcinoma is a very rare condition in childhood. There are only a few reports about adrenocortical carcinomas associated with congenital adrenal hyperplasia. A two-month-old male baby presented at the...
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The Effects of Galantamine Hydrobromide Treatment on Dehydroepiandrosterone Sulfate and Cortisol Levels in Patients with Chronic Fatigue Syndrome

Turan T, Izgi HB, Ozsoy S, Tanriverdi F, Basturk M, Asdemir A, Besirli A, Esel E, Sofuoglu S

  • KMID: 2315838
  • Psychiatry Investig.
  • 2009 Sep;6(3):204-210.
OBJECTIVE: Mental fatigue, cognitive disorders, and sleep disturbances seen in chronic fatigue syndrome (CFS) may be attributed to cholinergic deficit. A functional deficiency of cholinergic neurotransmission may cause the hypothalamic-pituitary-adrenal...
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Declining concentrations of dehydroepiandrosterone sulfate and free testosterone with advancing age

Han MS, Choi IJ

  • KMID: 1474966
  • Korean J Obstet Gynecol.
  • 2009 Jun;52(6):631-635.
OBJECTIVE: To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) or free testosterone (FT) levels and aging. METHODS:One hundred and thirty one women without androgen excess symptoms such as oligomenorrhea or...
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