J Bone Metab.  2017 Feb;24(1):31-36. 10.11005/jbm.2017.24.1.31.

The Association between Dehydroepiandrosterone Sulfate (DHEA-S) and Bone Mineral Density in Korean Men and Women

• Park SG
• Hwang S
• Kim JS
• Park KC
• Kwon Y
• Kim KC

• KMID: 2371830
• DOI: http://doi.org/10.11005/jbm.2017.24.1.31

Abstract

BACKGROUND
The relationship between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density (BMD) is controversial. And findings of most studies that have investigated this relationship are restricted to postmenopausal women. In this study, we investigated the relationship between serum DHEA-S and BMD in both men and women.
METHODS
This cross-sectional study evaluated a total of 294 healthy Korean participants through a medical examination program. And a subgroup of 154 participants was subjected to a longitudinal analysis. We measured BMD by dual energy X-ray absorptiometry and assayed DHEA-S by a chemiluminescent immunoassay.
RESULTS
We evaluated the association between serum DHEA-S concentration and BMD at the femur trochanter after adjusting for cofounders such as age, body mass index, lifestyle factors, serum cortisol level, serum insulin-like growth factor 1 (IGF-1) level, and sex. Through our longitudinal study, we found that the changes in BMD at the total spine, at the femur neck, and at the femur trochanter were all smaller in the ΔDHEA-S <0 group than in the ΔDHEA-S >0 group.
CONCLUSIONS
We found that there was a positive correlation between serum DHEA-S and femur BMD, which suggests that controlling serum DHEA-S levels may retard age-related BMD reduction in Koreans.

Keyword

Aging; Bone density; Dehydroepiandrosterone sulfate; Osteoporosis

MeSH Terms

Absorptiometry, Photon
Aging
Body Mass Index
Bone Density*
Cross-Sectional Studies
Dehydroepiandrosterone Sulfate*
Dehydroepiandrosterone*
Female
Femur
Femur Neck
Humans
Hydrocortisone
Immunoassay
Life Style
Longitudinal Studies
Male
Osteoporosis
Spine
Dehydroepiandrosterone
Dehydroepiandrosterone Sulfate
Hydrocortisone

Figure

• 

  Fig. 1 Mean bone mineral density (BMD) values according to dehydroepiandrosterone sulfate tertile categories. The mean estimated BMD values were calculated by one-way analysis of variance (ANOVA). *P<0.05: one-way ANOVA with Tukey's multiple comparison test.

• 

  Fig. 2 Association between changes in serum dehydroepiandrosterone sulfate (DHEA-S) level and changes in bone mineral density (BMD). *P<0.05. a)ΔBMD: change in BMD. b)ΔDHEA-S: change in serum DHEA-S.

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