Korean J Fertil Steril.  2002 Sep;29(3):209-214.

Clinical Consideration of Obese Infertile Women

• Nam YS
• Jeong CJ
• Kim NK
• Yoon TK
• Cha KY

Abstract

OBJECTIVE
To analyze the clinical characteristics of obese infertile women. MATERIAL AND METHOD: Height, weight, body mass index, menstrual pattern, glucose, insulin, glucose / insulin ratio, dehydroepiandrosterone sulfate (DHEA-S), testosterone, free testosterone and plasminogen activator inhibitor (PAI-1) of 15 obese infertile women were tested.
RESULTS
Of 15 obese infertile women, the number of diabetes mellitus, hyperinsulinemia, and insulin resistance was 2 (13%), 2 (13%), 2 (13%), respectively. The incidence of increased DHEA-S, testosterone, and free testosterone was 7 (47%), 1 (7%), 6 (40%), respectively. Notably, all patients showed increased PAI-1.
CONCLUSIONS
Obesity is associated with infertility as well as many kinds of health problems. Obesity is closely related to insulin resistance and it also causes hyperandrogenism. Increased PAI-1 is one of the important causes of thrombophilia. Consequently, in the workup of obese infertile patient, many aspects of health problems should be considered.

Keyword

Obesity; Infertility

MeSH Terms

Body Weight
Dehydroepiandrosterone Sulfate
Diabetes Mellitus
Female
Glucose
Humans
Hyperandrogenism
Hyperinsulinism
Incidence
Infertility
Insulin
Insulin Resistance
Obesity
Plasminogen Activator Inhibitor 1
Plasminogen Activators
Testosterone
Thrombophilia
Dehydroepiandrosterone Sulfate
Glucose
Insulin
Plasminogen Activator Inhibitor 1
Plasminogen Activators
Testosterone